Professor Xu Yahui in the expert lecture hall: A study on the efficacy and safety of four antidepressants in the treatment of chronic insomnia

Xu Yahui, Second Affiliated Hospital of Xinxiang Medical College

Purpose

To explore the effects of four antidepressants on sleep quality, daytime fatigue and sleepiness, anxiety and depression symptoms, blood pressure, blood sugar, and electrocardiogram in patients with chronic insomnia, in order to clarify the efficacy and safety of the four drugs in the treatment of chronic insomnia
.

method

120 patients with chronic insomnia were recruited and divided into agomelatine group, trazodone group, fluvoxamine group and mirtazapine group, 30 cases in each group
.

result

1.
General demographic data such as gender, age, education level, and PSQI, ISI, FFS, ESS, HAMA, HAMD, systolic blood pressure, diastolic blood pressure, blood glucose, heart rate, PR interval, QRS wave width, QTc interval of the four groups There were no statistically significant differences in baseline levels before and after treatment
.

2.
Compared with before treatment, the PSQI score, ISI score and FFS score of the four groups were decreased, and the ESS score was increased after 4 weeks of treatment.
The ESS score increased in the zapine group
.

3.
Compared with before treatment, the HAMA scores and HAMD scores of the four groups were decreased after 4 weeks of treatment; the trazodone group was lower than the mirtazapine group; the mirtazapine group was lower than the trazodone group and fluvoxamine group HAMD scores were lower in the agomelatine group than in the trazodone group
.

4.
Compared with before treatment, the systolic blood pressure and diastolic blood pressure of the four groups after 4 weeks of treatment were decreased to varying degrees, and there was no significant difference in blood glucose, heart rate, PR interval, QRS wave width and QTc interval
.

in conclusion

1.
All four drugs can improve sleep quality, insomnia severity, daytime fatigue experience, anxiety and depression symptoms in patients with chronic insomnia, and all can increase daytime sleepiness
.

2.
Trazodone is more effective than mirtazapine in improving anxiety symptoms in patients with chronic insomnia
.

3.