Professor Zhang Fan's team of Fudan University reported that the absorption / emission wavelength of organic cyanine dye J-aggregate is greater than 1300nm, which is used in the second window of near infrared biodynamic fluorescence imaging
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Last Update: 2020-02-06
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Source: Internet
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Author: User
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Recently, Professor Zhang Fan, Department of chemistry, Fudan University, reported the fd-1080 J-aggregate, a near-infrared imaging probe with a maximum absorption and emission wavelength greater than 1300 nm In the experiment, the self-assembly of the cyanine dye fd-1080 was induced by phospholipid with good biocompatibility to form J-aggregates with regular arrangement Compared with the dye monomer, the maximum absorption and emission peaks of J-aggregate are shifted by 300 nm, and the second window of near-infrared dynamic angiography monitoring above 1500 nm is successfully realized Relevant research papers were published in J am Chem SOC (DOI: 10.1021 / JACS 9b10043) under the title of "J-aggregates of cyanine dynamic for nir-ii in vivo dynamic vasular imaging beyond 1500 nm" Sun Caixia and Li Benhao, doctoral students of Professor Zhang Fan's research group, are co authors of the paper Accurate biomedical imaging is very important for the diagnosis and prognosis of diseases Among them, fluorescence imaging has the advantages of high sensitivity, resolution and fast response, but the depth of tissue penetration is low In recent years, researchers have found that near-infrared second window fluorescence has great potential for in vivo imaging, especially for photons in the range of 1500-1700 nm, where biological tissues have lower scattering, absorption and spontaneous fluorescence This discovery has led to the rapid development of in vivo optical imaging, including carbon nanotubes, quantum dots, rare earth nanoparticles and other new near-infrared second window probes attracted the attention of researchers Compared with the above inorganic materials, organic molecular probes have the advantages of small relative molecular weight, easy metabolism, low biological toxicity, and have greater potential for the future biomedical transformation However, at present, it is difficult to achieve the maximum absorption wavelength and emission wavelength of more than 1300 nm only through structural modification Therefore, it is urgent to develop a simple preparation method to expand the maximum absorption and emission wavelengths of organic fluorescent dyes, and to be used for biological imaging in the near-infrared second window region in the range of 1500-1700 nm To solve these problems, Professor Zhang Fan's research team successfully developed a new near-infrared second window fluorescent dye fd-1080j-aggregate by self-assembly of phospholipid-induced cyanine dye fd-1080 Its maximum absorption and emission wavelengths are at 1360 nm and 1370 nm respectively, and it has excellent water solubility and optical stability The interaction between phospholipid and cyanine dye fd-1080 in the formation of J-aggregates was demonstrated by molecular dynamics simulation In vitro and in vivo imaging experiments show that compared with the imaging region with shorter wavelength, the fluorescence imaging at 1500 nm has better penetration depth, imaging resolution and signal-to-noise ratio In addition, the researchers also successfully used J-aggregate to realize the real-time monitoring of the hypotensive effect of isoket in hypertensive rats This work has been greatly supported by the Department of chemistry of Fudan University, Advanced Materials Laboratory of Fudan University, State Key Laboratory of polymer molecular engineering, Shanghai Key Laboratory of molecular catalysis and functional materials, national major research program, National Science Foundation for Distinguished Young Scholars, and key basic research projects of Shanghai Science and Technology Commission.
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