Professor Zhao Shimin, Fudan University: With a "simple heart", we have created many milestones in the field of metabolism.

Guide: More than ten years of basic scientific research, I 'enjoy it'.
Shimin zhao is the head of the metabolic and disease research team at Fudan University, the chief scientist of the National Protein Major Research Program, and a leader in scientific and technological innovation selected for the 10,000 People Program.
"more than a decade of basic scientific research, I 'enjoy it'."
recently, in an interview, Professor Zhao Shimin summed up his scientific research career.
1, the metabolic research at the "molecular" level, change the paradigm of cancer diagnosis and treatment Professor Zhao Shimin's metabolic and disease research team mainly research direction includes metabolite perception and signaling, nutrient metabolite disorders pathogenicity, disease-related protein translation and new modification.
that since 80 percent of human diseases are metabolic, digging up the secrets of metabolism can help us find the key to fighting disease.
Professor Zhao Shimin has been focusing on "metabolic regulation" research for more than 10 years, during which a number of original breakthroughs have been made, including "acetylation modification generally regulates human metabolic enzymes", "metabolites 2HG carcinogenic" and other subversive results, for cancer treatment has opened up a new direction, and won international recognition, was written into textbooks.
" is different from the traditional concept of nutritional metabolism, no longer limited to diet, digestion.
" Professor Zhao Shimin said, "Our work ionizes deep into the molecular level and analyzes the effects of metabolic compounds on cells and their signaling pathways."
if these molecules are well regulated, they contribute to health.
, once dysfunctional, can lead to disease, including cancer.
"Our study confirms that metabolites carry properties of 'signals'.
this is a transformative development.
now, more and more people realize that tumors are a systemic disease.
this fits with the concept of metabolism.
, we may be able to achieve a steady-state balance by interfering with the body's environment, thus achieving a model of 'peaceful coexistence' between the body and the tumor.
" interview, he offered such a thought.
2, the new study revealed "amino acid perception", filling the gap in the field In January 2018, Cell Metabolism, the top journal in the field of metabolism, published the latest results of Zhao Shimin's team in the form of a cover article - amino acid perception and signaling mechanisms, answering the basic questions of amino acid metabolism.
amino acids are the main components of the protein of the basic nutrients of life, and are also the only source of nitrogen in the body.
" primary nuclear organism acquires natural nitrogen by fixing nitrogen, a process that consumes 15 percent of its total energy.
means that this element is valuable, for which the original nuclear organism has its own monitoring system (to assess whether nitrogen is sufficient).
," says Professor Zhao Shimin, "for higher organisms, we get nitrogen from amino acids."
, the body also needs to perceive amino acid levels.
" foundation of the "amino acid perception" topic of popularity.
past, scientists have only sporadicly found proteins that sense amino acid levels and have yet to have a major impact.
Now, Professor Zhao Shimin's team has discovered a system of perception of 20 amino acids in human cells -- specifically, all amino acids that produce aminoAMPs catalyzed by the amino acid tRNA synthase, which in turn prompts the discovery of amino acids.
modified lysine is responsible for perceiving and transmitting levels of specific amino acids to maintain balance.
3, experienced the decades of changes in Chinese scientific research, will continue to explore the unknown in 2000, the Ph.D. in biochemistry, Zhao Shimin did not choose to continue his studies, but "jumped out" of the pharmaceutical circle - in the well-known consumer goods company Procter and Gamble (P.G.) work.
, he returned to Fudan University to form a team and concentrate on scientific research.
the reasons for these "risky" choices, Professor Zhao Shimin replied with a smile: "I've always been very clear about returning home."
study abroad and work for a foreign company, just in time for the country to start paying attention to basic research.
lucky enough to join Fudan, round the dream of being a teacher.
"Why is it related to the research direction of metabolic regulation?" Professor Zhao Shimin thinks it is a natural process of chance coincidence.
Combined with the educational background of biochemistry, let him in the field of metabolism " such as fish water" - in Science, Cell, Cancer Cell and other authoritative journals published a number of research results, has won the Ministry of Education first prize in natural science, talk about life science innovation award, and was shortlisted for the "Changjiang Scholars" award program, "people plan" scientific and technological innovation leader, as the country's major scientific research program chief scientist.
Zhao Shimin has participated in the Cold Spring Harbor Asia Conference many times, which is a microcosm of China's scientific research integration with the world.
: "At present, the domestic scientific research atmosphere is good, remarkable achievements, in terms of funding, hardware, communication and other aspects have a big change."
2017 alone, Chinese scholars published about 70 academic papers in Nature, Science and Cell, a goal that could not have been achieved 10 years ago.
past, we attended the Cold Spring Harbor Conference with a learning attitude.
, more and more Chinese originals are making foreign scholars 'bright'.
's a good trend.
" finally, the reporter asked Professor Zhao Shimin to choose a word to sum up his pursuit of the cause, his answer is "simple" - not driven by material, famous, with a heart to adhere to exploratory research.
.