Professors Zhang Yan and Wang Shuo, Nanjia University: 2-amino-1-methyl-6-benzene-based methane and the composition of intestinal bacteria in rats

2-amino-1-methyl-6-benzene-methane and s.4,5-b-phenylimidazo (2-Amino-1-methyl-6-phenylimidazo (4,5-b)pyridine, PhIP) is one of the most abundant heterocyclines, and is a common carcinogen in hot-processed protein-rich foods. Studies have shown that PhIP can induce colon tumors in rodents, but its mechanism is unclear. Xiuli Zhao of Tianjin University of Science and Technology's National Key Laboratory for Food Nutrition and Safety and Yan Zhang, Shuo Wang, and Yan Zhang, Shuo Wang, and others from Nanca University School of Medicine aim to explore PhIP-induced colon damage in rats. 16S rRNA gene sequencing and metabolomic results show that PhIP destroys the composition of gut bacteria and affects the metabolism of glycelin phospholipids and liouric acid. At the same time, PhIP inhibits lipid metabolism in the gut bacteria. Notably, transcriptional histology revealed that PhIP significantly inhibited the expression of a collection of genes in the colon associated with steroid hormone biosynthetics, fatty acid extension, fatty acid degradation, and glycoplasmic metabolism pathways. The results provide a new perspective for studying the mechanism of PhIP induced colon damage and provide a theoretical basis for further understanding the toxicity of PhIP.
About
Professor Zhang Yan
Zhang Yan, 131 first-level candidates for innovative talent engineering, doctoral tutors
I, educational background
1989.09---1993.07 Hebei agriculture University College of Agriculture
1994.09--- 1997.07 Master's degree in Food Science and Technology, Central Agricultural University of China
2001.09---2005.04 Food Engineering and Biotechnology, Tianjin University of Science and Technology Ph.D
.
, Work Experience
1997.07--- 1999.10 Assistant Professor, Tianjin University of Science and Technology
1999.11--- 2004.10 Lecturer, Tianjin University of Science and Technology
2004.11--- 2009.10 Associate Professor, Tianjin University of Science and Technology
2009.11---2018.01 Professor, Tianjin University of Science and Technology
2009.09--- 2010.03 FDA Center for Food Safety and Technology Research, Visiting Scholar
2018.01--- So far Nankai University Professor
III, research direction
1. The mechanism of producing health hazards in food processing, the mechanism of harmful effect and dietary nutrition intervention
2. Quality and safety control technology of food processing process
3. New technology for rapid detection of food safety
Professor Wang Shuo
, recipient of the National Science Fund for Distinguished Young People, doctoral tutor, leading talent in scientific and technological innovation of the National "Million People Plan", enjoy special allowances from the State Council. He is an expert expert of the Expert Group on "Key Technology Research and Industrialization Development of Food Processing" of the "11th Five-Year Plan" National Science and Technology Support Plan, an expert of the Expert Group on Food Manufacturing and Safety Technology in the Field of Modern Agricultural Technology of the 12th Five-Year Plan, and a member of the Youth Science and Technology Committee of the China Food Science and Technology Association. He is currently a member of the editorial board of LWT-Food Science and Technology, Journal of Agricultural and Food Chemistry. To the first finisher won the second prize of national scientific and technological progress 1, Tianjin science and technology progress first prize 1 and so on.
, Education
1987.9--- 1991.7 Bachelor of Environmental Biology, Department of Environmental Sciences, Nan kai University
1992.5--- Agriculture, Food and Master of Science
1995.9--- 1999.3 Ph.D., School of Agriculture, Food and Natural Resources, University of Sydney, Australia
II, Work Experience
1991.7---1992.4 Tianjin Institute for environmental science conservation
1999.3--- 2001.3 University of Sydney, Australian Federal Institute of Science and Industry Postdoctoral Fellow
2001.3--- 2003.9 University of Sydney, Australian Federal Science and Industry Research Institute
2003.9---2017.3 Special Professor of Tianjin University of Science and Technology
2017.3---

1. Research and development of small molecule immuno-testing theory and new
2. Research and development of "bionic antibody" synthesis and reaction theory and detection technology of alternative biological antibody
3. Quality and safety control technology of food processing
4. Food safety risk assessment
yl-6-phenylimidazo .4,5-b'pyridine Colon Injury by Disrupting the Intestinal Berry Composition and Lipid Metabolic Pathways in Rats published online at Journal of Agricultural and Food Chemistry.