Progesterone was found to be rich and transformed in thyroid

Xu Chengrong, a researcher at the South China Sea Oceanographic Research Institute of the Chinese Academy of Sciences, and Zhao Jianliang, a researcher at South China Normal University, have made important progress in the study of bio-rich and bio-transformation laws of typical progesterone in thyfish, the results of which were published in Environmental Science and Technology.
as an important member of steroid hormones, widely used in contraception and treatment of hormone-induced diseases, progesterone in recent years in the water environment is frequently detected.
team artificially added the environmental concentration of the progesterone drug CPTA to the laboratory simulation system, and for the first time systematically studied the absorption and purification process, metabolite structure and metabolic pathways of progesterone in different tissues of thyfish. The results show that the absorption and purification rate of CPTA in salmon tissue is fast and can be balanced within a few days. Muscle tissue is the main storage tissue of CPTA, although the residual CPTA concentration in contaminated fish is low, but most CPTA enters the fish body, mainly through dechlorination, hydrolysing, hydrogenation and hydroxylation into metabolites, and continues to remain in different tissues of the fish. At the same time, the researchers also detected dynamic changes in CPTA exposure of seven endogenetic hormones, suggesting that the endogenetic hormone cortisol in the blood and liver can act as an indicator of CPTA exposure at short-term low concentrations.