Progress has been made in the study of swine fever and natural immunity

Jinding, a professor at the School of Veterinary Medicine of South China Agricultural University and the Guangdong Provincial Laboratory of Modern Agricultural Science and Technology in Lingnan, has made important progress in the study of swine fever and natural immunity. The study was published recently in Autophagy.
is an acute, hot, highly contact infectious disease caused by swine fever virus, which is classified as Class A infectious disease by the World Organization for Animal Health. Swine fever virus infection caused disease, immune mechanism is unknown, seriously hinder the prevention and control of the disease, if you want to effectively prevent and control swine fever, swine fever disease, immune mechanism of this scientific problem in-depth study.
Chen Jinding's preliminary research confirmed that autophagy, as an inherent protective mechanism of cells, not only can not effectively remove the swine fever virus in the cells, but is held hostage by swine fever virus to promote the replication and release of sub-viruses, swine fever virus-induced autophagy inhibits apoptosis by lowering the RLR signal.
To further explore the immune mechanisms of swine fever virus infection, the researchers found that swine fever virus-infected cells activate signaling path paths such as Ca
cyto-CAMKK2-PRKAA-MTOR, AKT-MTOR, MAPK1/3-MTOR, and promote replication of swine fever virus. At the same time, the swine fever virus non-structural protein NS5A can act with HSP90AB1, through the CAMKK2-PRKAA-MTOR signaling pathway to mediate cell autophagy occurred, and then induced the natural immune signaling pathway RLR inhibits the production of type I interferon.
this study reveals for the first time how swine fever virus infection induces autophagy and inhibits the secretion mechanism of type I interferon through RLR signaling. These findings will provide new understanding of the pathogenesis and viral immune escape mechanisms of swine fever and accelerate the development of potential antiviral drugs. (Source: China Science Journal Zhu Hanbin Chen Weichen)
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