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Progress in the evolution of insulin gene transcription regulation pathways |
Recently, "Nature-Communications" reported online the results of collaborative research between Xu Fei, an associate researcher of the Institute of Oceanology of the Chinese Academy of Sciences , and British scientists
.
The study used oyster oysters as the object, using bioinformatics and molecular biology techniques to prove the existence of the Pdx-insulin regulatory pathway in oyster oysters, indicating that the function of the key transcription factor Pdx to regulate insulin gene expression can be traced back to the common ancestor of bilaterally symmetrical animals
Chinese Academy of Sciences
James Collip, a major participant in insulin purification work, began to pay attention to the existence of insulin in different animals since the discovery of insulin, and in 1923, he identified the existence of substances similar to insulin activity in the bivalve Myraea
.
However, more and more studies have shown that invertebrate and vertebrate insulin-like genes are very different in structure and expression patterns
With the continuous accumulation of genomic information, scientists realized that marine crested animals may have a more primitive and universal genetic composition
The study further explored the homology of animal intestinal system through transcriptome technology, and found that shellfish and vertebrate midgut system have greater functional similarities, and the shellfish "hepatopancreas" and the complex intestinal system of vertebrates are independent of each other.
Evolution, but may all originate from the endoderm region where the Pdx gene is expressed
.
The transcriptional regulatory region of cgILP gene and the binding motif of cgPdx gene were identified by targeted open chromatin technology
The above-mentioned research was jointly funded by the National Natural Science Foundation of China, the key deployment project of the Ocean Science Center of the Chinese Academy of Sciences, and the China Scholarship Council
.
(Source: China Science News, Liao Yang and Wang Min)
Information about the paper: https://dx.
https://dx.
doi.
org/10.
1038/s41467-021-23216-7