echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Food News > Food Articles > Progress in the evolution of insulin gene transcription regulation pathways

    Progress in the evolution of insulin gene transcription regulation pathways

    • Last Update: 2021-06-16
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    Progress in the evolution of insulin gene transcription regulation pathways
    Progress in the evolution of insulin gene transcriptional regulation pathways.


    Recently, "Nature-Communications" reported online the results of collaborative research between Xu Fei, an associate researcher of the Institute of Oceanology of the Chinese Academy of Sciences , and British scientists
    .


    The study used oyster oysters as the object, using bioinformatics and molecular biology techniques to prove the existence of the Pdx-insulin regulatory pathway in oyster oysters, indicating that the function of the key transcription factor Pdx to regulate insulin gene expression can be traced back to the common ancestor of bilaterally symmetrical animals


    Chinese Academy of Sciences

    James Collip, a major participant in insulin purification work, began to pay attention to the existence of insulin in different animals since the discovery of insulin, and in 1923, he identified the existence of substances similar to insulin activity in the bivalve Myraea
    .


    However, more and more studies have shown that invertebrate and vertebrate insulin-like genes are very different in structure and expression patterns


    With the continuous accumulation of genomic information, scientists realized that marine crested animals may have a more primitive and universal genetic composition


    The study further explored the homology of animal intestinal system through transcriptome technology, and found that shellfish and vertebrate midgut system have greater functional similarities, and the shellfish "hepatopancreas" and the complex intestinal system of vertebrates are independent of each other.
    Evolution, but may all originate from the endoderm region where the Pdx gene is expressed
    .


    The transcriptional regulatory region of cgILP gene and the binding motif of cgPdx gene were identified by targeted open chromatin technology


    The above-mentioned research was jointly funded by the National Natural Science Foundation of China, the key deployment project of the Ocean Science Center of the Chinese Academy of Sciences, and the China Scholarship Council
    .


    (Source: China Science News, Liao Yang and Wang Min)

    Information about the paper: https://dx.


    https://dx.
    doi.
    org/10.
    1038/s41467-021-23216-7
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Related Articles

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.