Progress in the study of chemical composition and pharmacological activity of african medicinal plants

Most of Africa is located in the tropics, the average elevation is second only to Antarctica, from north to south in order to the Sahara Desert, the Congo Basin, the Great Rift Valley of East Africa and the South African Plateau, the climate is characterized by high temperature, little rain, dry, the distribution of the climate belt is north-south symmetryAfrica's geographical and climatic factors are complex, rainfall differences, vertical temperature differences, its unique ecological environment, creating the African continent rich and unique biodiversity, of which medicinal plants have become the African local population to prevent disease and ensure health of the most important natural productsThe advantage of "non-drug" is that the special climate and geographical environment create the remarkable characteristics of the accumulation of specific active ingredients and their corresponding biological activityBitter suis is a versatile species of male and female tree that is used to treat a variety of diseases, for example, flowers are used as a drink for the treatment of intestinal parasitic diseases, and roots in Africa can be used in combination with other plant drugs to treat cancerBut so far, there has been little research on the specific chemical composition of these specific drugs that correspond to the biological activity in the bitter su, Under the guidance of researcher Guo Mingquan, A PhD student in the Key Laboratory of Plant Seed Innovation and Characteristic Agriculture at Wuhan Botanical Garden of the Chinese Academy of Sciences, and based on recent research findings, antioxidant activity may also be one of the most important ways to suppress tumor cells, using high-efficiency liquid chromatography-mass spectrometry techniques (LC-MS) and nuclear magnetic resonance (NMR) to identify a series of compounds with antioxidant and anti-tumor cell proliferation from bitter suFirst, combined with the determination of the content of total flavonoids and phenolic substances at different active sites of bitter suander and antioxidant activity screening (DPPH free radical removal capacity, ABTS free radical removal ability and iron ion reduction ability), the active site of acetate is screened to the relatively high antioxidant activity in the bitter suSecondly, combined with anti-
tumorcell proliferation activity screening, found that the anti-proliferation activity of the three cancer cells in the ethyl acetate site was higher than that of other partsThus, the active site of bitter su, then using LC-MS and NMR to isolate and identify the active ingredients of bitter sugen, analysis and identification of nine main lysing acid and flavonoid serotonin components, and in the MTT experiment found that quercetin to colon cancer cells (HT-29) andliver cancercells (HepG2) inhibited proliferation activity, DPPH experimentfound strong antioxidant activityThese results provide a scientific basis for the traditional application of bitter su, which can be further developed and utilized(
Bioon.com of Biological Valley)