Progress in the study of noninvasive ultrasound nerve regulation in free-moving mice.

Recently, Zheng Hairong, a researcher at the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, made new progress in the field of ultrasonic nerve regulation, and the results of the work of brain nerve regulation and retinal nerve regulation were published in the IEEE Transactions series.
team led the study of ultrasonic nerve regulation in free-moving mice.
related work Non Ultrasonic Neuromodulation in Freely Moving Mice ("Non-invasive ultrasound neuromodulation research in free-moving mice") is published in the biomedical engineering journal IEE TransactionE on Biomedical Engineering, DOI: 10.1109/TBME.2018.2821201). The
team developed a small, lightweight head-mounted ultrasonic stimulation device for the application of ultrasonic nerve regulation technology in sober rodent experimental animals.
the device can not only meet the demanding requirements of the head-wearing device in sober small animals, but also attach the installation of electrophysiological collection electrodes, administration tubes and optical fiber accessories, to achieve ultrasonic neuroregulation and electrophysiological, drug administration, photostimulation and calcium imaging and other multi-modal nerve regulation, evaluation methods, promote ultrasonic neuroregulation technology in epilepsy, depression, Parkinson's disease, drug addiction and sleep dysfunction and other research areas of the application of diseases.
the study developed a headset of different sizes, and for the first time successfully achieved ultrasonic regulation of the behavior of free-moving mice.
the research results provide new tools for expanding the application of ultrasonic neuroregulation technology in the field of exploring the mechanism of ultrasound and the intervention of brain diseases (Figure 1).
, the team has made new advances in the study of retinal ultrasound stimulation.
work Temp Neurooralmodulation of RetinaGlion Cells by Low-frequency Turbo Turbo ("Time neuromodulation Study of Low-Focus Ultrasound Stimulates Retinal Neurocell Cells") is published in the Journal of IEEE Transactions on The Neural Systems and Rehabilitation Engineering (IEEE Neurology and Rehabilitation Engineering Journal, DOI: 10.1109/TNSRE.2018.20119.
retinal degenerative diseases include retinal pigmentation and geriatric macular degeneration, which are mainly manifested in the apoptosis of photoreceptors, which in turn lead to blocked visual signal input.
in recent years, implantable visual prosthetics have made significant progress in the treatment of neuropathy.
however, implantable medical devices are highly intrusive and have many safety, effectiveness and cost issues.
ultrasound, as a new kind of neural regulation, has the advantages of non-invasive regulation, and has received great attention in the field of retinal prosthesis research.
the first study of stimulating the retina of the offly body in rats using low-frequency focused ultrasound with a frequency of 2.25 MHz.
studies have found that low-frequency focused ultrasound can effectively induce different types of reactions in retinal nerve cell, and compared the time response characteristics of retinal nerve cell at different ultrasonic intensity, the results of which will promote the realization of non-invasive ultrasound retinal prosthesis (Figure 2).
the above-mentioned research work has been supported by the National Natural Science Foundation of China national major scientific research instrument development project, Guangdong Province innovation team and Shenzhen Peacock team and other projects.
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