Progress was made in the evaluation of silver ring snake toxin and clinical anti-silver ring snake serum

Snake injury is a tropical disease, due to economic reasons or lack of treatment drugs - anti-snake venom serum, resulting in snake injury patients have a higher disability rate and a certain mortality rate.
The Biotoxin and Human Diseases Unit of the Kunming Institute of Zoology of the Chinese Academy of Sciences studied silver ring snakes and obtained high-purity a-bungarotoxin, b-bungarotoxin and g-bungarotoxin by traditional separation and purification methods.
half of its lethal dose was measured by three different dosage methods, and it was determined that b-bungarotoxin was the most toxic and highly contained toxin, the most important component of silver ring snake bite death, and that individual anti-b-bungarotoxin antibodies were effective in mesolyticing silver ring snake toxin.
, the researchers conducted antibody protection experiments on commercial anti-silver ring snake venom and nine species of poisonous snakes that were seriously harmful.
the study found that commercial anti-silver ring snake venom blood removed can be mediumed silver ring snake toxin, cobra snake toxin also has a certain protective effect, but the cobra venom and the same species of silver ring snake snake venom basically no protective effect, this conclusion provides guidance and experimental basis for anti-silver ring snake serum treatment of snake injury.
research results on Immunoreactivity and neutralization study of Chinese Bungarus multicinctus antivenin and lab-prepared anti-bungarotoxin antisera directs purified bungarotoxins and snake venoms were published in a cover article on PLoS Neglected Tropical Diseases.
Wenhui, an associate researcher at Kunming Animal Institute in China, and Wu Xiaobing, a professor at the School of Life Sciences at Anhui Normal University, are co-authors of the paper.
Lin Bo of Anhui Normal University and Zhang Jiarui, a graduate student at Guangzhou Medical University, are co-authors of the paper.
research has been supported by Yunnan Province's key areas and key research and development programs.
(）