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    Home > Biochemistry News > Biotechnology News > Qian Feng's research group from the School of Pharmacy, Tsinghua University has made a series of new progress in the development of mAb aggregation kinetics, solution stability mechanism and application and development of high-concentration mAb preparations

    Qian Feng's research group from the School of Pharmacy, Tsinghua University has made a series of new progress in the development of mAb aggregation kinetics, solution stability mechanism and application and development of high-concentration mAb preparations

    • Last Update: 2022-05-12
    • Source: Internet
    • Author: User
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    1 nucleation growth onset
    Figure 1: Kinetic process of phase separation of monoclonal antibody solution - nucleation and growth
    .

    2
    Figure 2: Electrostatic interactions induce the formation of ATP-mAb complexes, which in turn alter the colloidal behavior of the solution
    .

    3
    Figure 3: The technical implementation path of monoclonal antibody suspension: 1.
    Use spray drying technology to prepare stable monoclonal antibody solid particles; 2.
    Select non-aqueous organic solvent to suspend monoclonal antibody particles to obtain high-concentration, low-viscosity suspension

    .



    1.
    Int J Pharm 2020


    2.
     
    Mol Pharm 2021


    3.
     
    Mol Pharm 2022



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