 Home > Biochemistry News > Biotechnology News > Qian Feng's research group from the School of Pharmacy, Tsinghua University published the latest scientific article in "Theranostics" "Macropinocytosis dextran assists the targeted delivery of drugs in KRAS-mutant pancreatic cancer"

Qian Feng's research group from the School of Pharmacy, Tsinghua University published the latest scientific article in "Theranostics" "Macropinocytosis dextran assists the targeted delivery of drugs in KRAS-mutant pancreatic cancer"

 Last Update: 2022-03-08
 Source: Internet
 Author: User

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blue dextran

microscopic cancer cells

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70kDa dextran has the potential to better target KRAS

Figure 1 70kDa Dextran has more significant KRAS targeting (A: 4kDa Dextran, B: 70kDa Dextran, C: 150kDa Dextran)

Conjugation of drugs to dextran enhances selectivity of drug delivery to KRAS-mutant cancer cells

Figure 2 DEX-TP enhances the toxicity against KRAS mutant pancreatic cancer cells and the ability to inhibit tumor growth

DEX-TP effectively inhibits the progression of orthotopic pancreatic tumors

Figure 3.
DEX-TP increases the inhibition of pancreatic orthotopic MIAPaCa-2 tumor growth

DEX-TP prolongs survival in KPC-transplanted mice and alleviates the immune depletion of TP

Figure 4 Therapeutic effect of DEX-TP on KPC xenograft orthotopic tumor model

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