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    Home > Biochemistry News > Biotechnology News > Qsp1: The sexual reproduction and subtraction of the human pathogen fungus neo-pylococcus.

    Qsp1: The sexual reproduction and subtraction of the human pathogen fungus neo-pylococcus.

    • Last Update: 2020-08-09
    • Source: Internet
    • Author: User
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    Wang Linqi, a national laboratory for mycology at the Institute of Microbiology of the Chinese Academy of Sciences, published the results of the study entitled Cryptococcus neoformans sexual lyis controlled by a quorum yn ysling in The Nature Microbiology.
    the study, which reported on the first case of eukaryotes dependent on cell density sensing signals (quorum sensing signals, also known as group effect signals), revealed the sexual reproduction and subtraction of the cell density sensor Qsp1 as a key extracellular signal ingon syntifying of important human pathogenic fungi (more than 200,000 deaths per year, with a fatality rate of 20%-70%).
    sexual reproduction is a fundamental form of reproduction of eyre, including fungi.
    fungi as an excellent research material for genetic operation is widely used to explore the functional role of sexual reproduction in environmental adaptation, species evolution and infectious diseases, of which the human pathogenic fungus neophycoccal is one of the model bacteria to study the sexual reproduction of fungi.
    the pathogen has two mating types (alpha and a) that can be sexually reproduced through two modes of alpha-a heterosexual reproduction and alpha same-sex reproduction.
    more than 99% of the strains in nature are alpha mating, alpha same-sex reproduction is considered to be the main sexual reproduction mode of the new cryptococcal bacteria.
    a growing number of studies have shown that alpha same-sex reproduction as an important adaptive behavior sustains the short-term adaptation advantages of neophycoccal sycoccal and its sister species, Gert cryptococcals, in host infection and long-term species advantages: first, same-sex spores, the product of alpha same-sex reproduction, can participate in early host lung implantation as important infectious reproductions;
    Wang Linqi's team's study found that, unlike most fungi with sexual reproduction, the initiation of cryptococcal alpha same-sex reproduction did not require the activation of the sexual pheromone signal (the classic fungus "sex hormone molecule") but was highly controlled by cell density.
    when the cell density increases, the cell density-sensing molecule Qsp1 accumulates in large quantities outside the cell, and high concentrations of Qsp1 molecule induce the occurrence of alpha-same-sex reproduction and then initiate a subtractive division process, which eventually leads to the production of highly infectious same-sex spores.
    researchers also found that Qsp1's activation of the same-sex reproductive process of cryptic bacteria required the involvement of a cell density response protein, Cqs2, which was combined with chromatin immunocoprecipitation technology through structural modeling, to confirm that Cqs2 was involved in regulating the activation of cell density-driven same-sex reproduction through an unreported DNA binding domain.
    sexual reproduction is an ancient form of eukaryotic reproduction, and the fossil evidence dates back 1.2 billion years to the narrow-ribbon period and is thought to have originated in the ancestors of single-celled eukaryotic seniles.
    recent lysage study by Joseph Heitman's laboratory at Duke University, cryptococcal alpha same-sex reproduction maintained the importance of sexual reproduction in early eukaryotic ancestors (not dependent on cell fusion but by increasing chromosomal multiplication through cell cycle regulation), representing an ancient form of sexual reproduction.
    , the study suggests that cell density-dependent group-sensing regulation may have played an important role as an ancient extracellular regulation in the sexual reproduction of eukaryotes ancestors.
    Wang Linqi's research has been supported by the Chinese Academy of Sciences' cutting-edge science key research project, the National Natural Science Foundation of China "excellent youth science fund", the face project, the "Youth Thousand People Program" of the Central Group Department, the national science and technology major special projects and other funds. Tian Xiuyun, Ph.D.,
    Microbiology Institute, Assistant Researcher He Guangjun and Ph.D. Student Hu Pengjie are co-first authors.
    Yang Enze of Peking University Medical Department used differential expression characteristic analysis and AIM-ding technology to help determine the key component of the new cryptococcal Qsp1 signal transduction pathway, Cqs2. The Wubian group of the
    Microbiology Institute has given important help in the modeling of Cqs2 protein structure.
    Professor Lin Xiaoxuan of the University of Georgia and the Microbiology Institute's Bai Fengyan Group supported the study and gave valuable advice.
    .
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