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    Home > [quick news] Wednesday, November 15, 2017

    [quick news] Wednesday, November 15, 2017

    • Last Update: 2017-11-15
    • Source: Internet
    • Author: User
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    Scientists have proposed a safer way to edit CRISPR gene MIT scientists have developed an alternative method to cas9 virus vector: nano particle method, which can integrate CRISPR mechanism into cells and edit their genomes And they proved the hope of the system by targeting PCSK9, which leads to a rare genetic form of high cholesterol In mice, they used a nanoparticles based CRISPR system to eliminate PCSK9 gene in more than 80% of hepatocytes Nature Biotechnology https://www.nature.com/articles/nbt.4005 drug registration application will be adjusted to be accepted by CFDA The State Food and Drug Administration recently issued the announcement on adjusting the acceptance of drug registration (No 134 in 2017), saying that all registration applications reviewed, approved and filed by the State Food and Drug Administration in accordance with the current laws, regulations and rules shall be accepted by the State Food and drug administration, including the application for clinical trials of new drugs and the production of new drugs (including new ones Drug certificate) application, generic drug application, supplementary application approved by the State Food and drug administration, etc.; drug registration application approved and filed by the provincial food and drug administration shall still be accepted by the provincial food and drug administration CFDA http://www.sda.gov.cn/ws01/cl0050/216762.html the molecular mechanism of non coding RNA in the proliferation of liver cancer cells is newly discovered Through quantitative proteomics technology, Gefeng research group of Institute of Hydrobiology, Chinese Academy of Sciences has found two kinds of molecular mechanisms of non coding RNA regulating the proliferation of liver cancer cells Noncoding RNA refers to RNA molecules that cannot encode proteins The noncoding RNAs with regulatory effects mainly include microRNAs, long-chain noncoding RNAs and circular RNAs The research results are of great significance for revealing the molecular mechanism of cancer occurrence and finding more effective treatment methods Journal of project research http://pubs.acs.org/doi/10.1021/acs.jproteome.7b00519 Molecular & cellular technologies http://www.mcponne.org/content/early/2017/10/27/mcp.ra117.000277.abstract BMS new drug against childhood leukemia approved by FDA recently The company's new drug, sprycel (dasatinib), was used to treat Philadelphia chromosome positive chronic myeloid leukemia (CML) in children with chronic phase (CP) The approval was carried out under the priority review of FDA and obtained the orphan drug qualification issued by FDA The safety and efficacy of sprycel in paediatric patients were evaluated in two studies involving 97 CP-CML patients Check orphan http://www.checkorphan.org/news/u-s-food-and-drug-administration-expands-approval-of-sprycel-r-dasatinib-to-include-treatment-of-children-with-philadelphia-chromosome-positive-chronic-myeloid-leukemia-in-chronic-phase HIV proliferation secret is "decoded" Scientists from Peking University and the University of Chicago in the United States used computer models to "decode" the unknown details of HIV transmission between cells, which is expected to find a new way to develop anti AIDS drugs They built a "coarsening" computer model that revealed the possible conformation of a protein called h1v-1gag on the cell membrane This kind of protein is the main assembly protein of the virus, which participates in budding, but scientists have been difficult to use experimental means to obtain clear images of the assembly process at the molecular level PNAS http://www.pnas.org/content/early/2017/10/31/1706600114.full
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