Radiology: 3T MR substantia nigra volume measurement for primary and advanced Parkinson's disease

In the research of Parkinson's disease, identifying a reliable in vivo marker that supports early diagnosis , monitors disease progression, and promotes therapeutic intervention is the top priority of all research
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The diagnosis of Parkinson's disease is based on clinical criteria, and it can be further diagnosed and analyzed through functional nuclear medicine neuroimaging of dopamine radioligands

In the research of Parkinson's disease, identifying a reliable in vivo marker that supports early diagnosis , monitors disease progression, and promotes therapeutic intervention is the top priority of all research

Recent developments indicate that MRI can be used to assess the substantia nigra, which is the main site of neurodegenerative disease in Parkinson's disease

Recently, a study published in the journal Radiology evaluated the supportive effect of MRI's quantitative measurement of substantia nigra volume on the clinical diagnosis and staging of Parkinson’s disease, paving the way for the wide application of MRI in the diagnosis and monitoring of Parkinson’s disease.

A total of 80 participants were included in the study for evaluation: 20 healthy control participants (mean age ± standard deviation, 56 years ± 11 years; 11 women), 29 patients with primary Parkinson's disease (64 years ± 10 years) ; 19 males), 31 advanced Parkinson's disease patients (60 years old ± 9 years old; 16 females)
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The measurement of the substantia nigra volume with high signal intensity through the magnetization transfer-prepared T1 weighted MRI sequence helps to distinguish between the healthy control group and the patients with advanced Parkinson's disease (ipsilateral mean difference, 64 mm ³ ±14, P <.

By magnetization transfer-prepared T1-weighted MRI volume measurements sequence nigra contributes to high signal strength to distinguish between healthy controls and advanced Parkinson's disease ^{3 3} also helps to distinguish between healthy controls and patients with idiopathic Parkinson ^{3 3} and patients with primary Parkinson's disease and patients with advanced Parkinson's disease ^{3 3}

The figure performs axial magnetization transfer-prepared T1-weighted MR imaging of the black matter regions of interest with high signal intensity on the left and right of the first 8 consecutive participants in each group
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A, healthy control group participants; B, primary Parkinson's disease participants; C, advanced Parkinson's disease participants

The figure performs axial magnetization transfer-prepared T1-weighted MR imaging of the black matter regions of interest with high signal intensity on the left and right of the first 8 consecutive participants in each group

Table: Receiver operating characteristic curve analysis summary
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Table: Receiver operating characteristic curve analysis summary
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In summary, the results of this study are clinically proposed and verified as a clinically feasible and reproducible MRI method for measuring the volume of the substantia nigra in Parkinson's disease, which satisfies the distinction between primary Parkinson's disease and health.
The clinical needs of individuals and advanced Parkinson's disease are therefore expected to become a valuable imaging marker for evaluating disease progression and treatment effects
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In summary, the results of this study are clinically proposed and verified as a clinically feasible and reproducible MRI method for measuring the volume of the substantia nigra in Parkinson's disease, which satisfies the distinction between primary Parkinson's disease and health.
The clinical needs of individuals and advanced Parkinson's disease are therefore expected to become a valuable imaging marker for evaluating disease progression and treatment effects
.

Original source:

Original source:

Paolo Vitali , Marina I Pan , Fulvia Palesi , et al.

The Vitali Paolo , Marina the I Pan , Fulvia Palesi , et Al.
Substantia Nigra Volumetry complex with the MRI.
3-T in De Novo Parkinson, Disease and Advanced .
The DOI: 10.
1148 / radiol.
2020191235 10.
1148 / radiol.
2020191235 in this message