Radiology: Don't use the same old method to evaluate the iron content of the brain tissue of AD patients!

Iron is a ubiquitous element in the human body and an indispensable cofactor for major biochemical processes (such as oxidative phosphorylation, oxygen transport, and neurotransmitter and DNA synthesis)
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According to reports, abnormal iron accumulation can be found in many neurodegenerative diseases

Iron is a ubiquitous element in the human body and an indispensable cofactor for major biochemical processes (such as oxidative phosphorylation, oxygen transport, and neurotransmitter and DNA synthesis)

At this stage, neuroimaging technology can detect the iron content of paramagnetic brain tissue in vivo

Recently, a study published in the journal Radiology used R2* relaxation rate mapping technology to compare the overall and regional iron content of brain tissue between AD patients and age-matched HC patients, and evaluated the 17-month follow-up of AD patients The longitudinal R2* changes during the period and the relationship between iron content data and cognitive decline have been determined, which provides a reference for the clinical further clarification of the mechanism and pathological process of AD, and provides technical support for the early diagnosis and treatment of AD

A total of 100 AD patients (mean age 73±9 years [standard deviation]; 58 women) and 100 age-matched HC participants (mean age 73±9 years; 60 women) were evaluated
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AD group BG (HC, 29.

AD group the BG ^{-1; -1} total neocortex ^{-1 -1} occipital ^{-1 -1} temporal ^{-1 -1} bits in the R2 * HC were higher than in AD patients, temporal lobe and R2 * value Al The longitudinal change of Zheimer's disease total score is related to ^-1 , but not related to the longitudinal change of brain volume

Figure 1 R2⁎map of healthy control participants and AD patients
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The difference in iron concentration in the basal ganglia is too small to be visually distinguished between AD patients and healthy controls, and the iron content level depends largely on the anatomy and age of the subjects

Figure 1 R2⁎map of healthy control participants and AD patients

Figure 2 The R2⁎map of a participant in the study superimposed on the cortical and subcortical segmentation
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Figure 2 The R2⁎map of a participant in the study superimposed on the cortical and subcortical segmentation
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Table AD patients and healthy control group participants in different brain regions of R2 * value
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Table AD patients and healthy control group participants in different brain regions of R2 * value
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This study shows that the iron content of deep gray matter and neocortex in Alzheimer's disease patients is higher than that in healthy controls
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Over time, changes in the iron content of the temporal lobe are related to the cognitive decline of patients with Alzheimer's disease

This study shows that the iron content of deep gray matter and neocortex in Alzheimer's disease patients is higher than that in healthy controls

Original source:

Anna Damulina , Lukas Pirpamer , Martin Soellradl , et al.

Damulina anna , Lukas Pirpamer , Martin Soellradl .
, Et Al Cross-sectional and Longitudinal Assessment of Brain Iron Level of Alzheimer Disease in the Using the MRI.
3-T .
The DOI: 10.
1148 / radiol.
2020192541 10.
1148 / radiol.
2020192541 in this message