Radiology: DTI Identifies Sexual lysergic paralysis and Louis small body disease
Last Update: 2020-06-16
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Background Due to the overlay of symptoms, the identification of progressive nuclear paralytic paralysis (PSP) and Louis small body diseases, including Louis small body Parkinson's disease and dementia, can be challengingObjective The purpose of this study is to establish a diagnostic method for identifying PSP and Louis small body diseases based on diffuse cheometric imaging (DTI)Materials and Methods In this retrospective study, two data-enabled DTI indicators are extracted: the establishment of samples and the validation of samplesBased on previous neuroimaging studies and neuropathological evidence, some regions are very sensitive to the detection of PSP pathological features (precipitous lysoper, prefrontal white matter), and some anisotropy (FA) can be used to score FA for each patientThe classification efficiency was evaluated by using logistics regression and ROC curve analysisResults A total of 16 PSP patients, 34 patients with Louis small body disease and 44 healthy volunteers were evaluated in the discovery groupThe FA score identifies the area, specificity, and sensitivity under the ROC curve of clinical PSP and Louis small body diseases, respectively, 0.97 ,0.04, 91% (31 of 34), and 94% (15 of 16)In the validation group, 34 psP patients, 25 cases of Louis small body disease and 32 healthy volunteers were evaluatedThe accuracy of the FA score has been verified (area, specificity, and sensitivity under the ROC curve are 0.96 , 0.04, 96% , 24 of 25, 85% , 29 of 34 , respectively)Conclusion The results of this study lay the foundation for clinicalidentification of nuclear onsic paralysis and Louis small body disease
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