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    Home > Active Ingredient News > Antitumor Therapy > Radiology: Good news for patients with colorectal cancer and liver metastases!

    Radiology: Good news for patients with colorectal cancer and liver metastases!

    • Last Update: 2021-07-27
    • Source: Internet
    • Author: User
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     Colorectal cancer is the fourth most common type of cancer in the world, and about 45% of patients have liver metastases
    .
    Surgical resection is the main treatment for this type of disease, and its 5-year overall survival rate (OS) is between 28% and 57%


    .


     Colorectal cancer is the fourth most common type of cancer in the world, and about 45% of patients have liver metastases


    Percutaneous radiofrequency ablation (RFA) has been widely used in liver malignancies and is the standard treatment for primary hepatocellular carcinoma


    Recently, a study published in the journal Radiology evaluated the local tumor progression-free survival (LTPFS) of patients with CLM undergoing RFA, and proposed an algorithm strategy to predict LTP based on clinical variables, providing an early and accurate screening for the clinic Suitable imaging methods for CLM patients undergoing RFA


    This study included 365 patients (average age 60 ± 11 years [standard deviation]; 259 males), a total of 512 CLMs for evaluation
    .
    LTPFS and OS were 85% and 92% at 1 year, 73% and 41% at 5 years, 72% and 30% at 10 years, and 72% and 28% at 15 years


    .


    The independent risk factors for LTP include tumors greater than or equal to 2cm , subcapsular tumor location, and minimum ablation margin ≤5mm.


     

    Figure 1 Kaplan-Meier curve of local tumor progression-free survival (LTPFS) in the entire cohort


    .


    Figure 1 Kaplan-Meier curve of local tumor progression-free survival (LTPFS) in the entire cohort


     

    The table uses univariate and multivariate Cox proportional hazards models to evaluate the results of 316 patients with colorectal cancer with liver metastases after radiofrequency ablation for local tumor progression-free survival related factors


    .


    The table uses univariate and multivariate Cox proportional hazards models to evaluate the results of 316 patients with colorectal cancer with liver metastases after radiofrequency ablation for local tumor progression-free survival related factors


     

    Figure 2 Kaplan-Meier curve of overall survival (OS) in the entire cohort


    .


    Figure 2 Kaplan-Meier curve of overall survival (OS) in the entire cohort
    .

    In summary, radiofrequency ablation has a long-term control effect on the treatment of patients with colorectal liver metastases
    .
    The position under the tumor capsule, tumor diameter ≥ 2 cm, and minimum ablation margin ≤ 5 mm are related to local tumor progression
    .
    Although the smallest ablation margin ≤ 5mm is the most important factor, compared with the model that only uses the smallest ablation margin, the multivariate method using all independent risk factors can better predict the local tumor progression-free survival
    .
    This study provides a clinical imaging method to screen the best subjects for radiofrequency ablation treatment and to predict the prognosis of patients early
    .

    In summary, radiofrequency ablation has a long-term control effect on the treatment of patients with colorectal liver metastases
    .
    The position under the tumor capsule, tumor diameter ≥ 2 cm, and minimum ablation margin ≤ 5 mm are related to local tumor progression
    .
    Although the smallest ablation margin ≤ 5mm is the most important factor, compared with the model that only uses the smallest ablation margin, the multivariate method using all independent risk factors can better predict the local tumor progression-free survival
    .
    This study provides a clinical imaging method to screen the best subjects for radiofrequency ablation treatment and to predict the prognosis of patients early
    .

    Original source:

    Original source:

    Kichang Han , Jin Hyoung Kim , Seul Gi Yang ,et al.
    A Single-Center Retrospective Analysis of Periprocedural Variables Affecting Local Tumor Progression after Radiofrequency Ablation of Colorectal Cancer Liver Metastases .
    DOI: 10.
    1148/radiol.
    2020200109

    Kichang Han , Jin Hyoung Kim , Seul Gi Yang ,et al.
    A Single-Center Retrospective Analysis of Periprocedural Variables Affecting Local Tumor Progression after Radiofrequency Ablation of Colorectal Cancer Liver Metastases .
    DOI: 10.
    1148/radiol.
    2020200109 10.
    1148/radiol.
    2020200109 here message
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