Radiology: MRI scan allows the progression and outcome of Parkinson's disease in one step!

Traditionally , Parkinson's disease (PD) was considered a movement disorder, but with the advancement of technology , it is now clinically recognized that some non-motor symptoms are also part of PD
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Cognitive decline is one of the most common non-motor symptoms of PD

Traditionally , Parkinson's disease (PD) was considered a movement disorder, but with the advancement of technology , it is now clinically recognized that some non-motor symptoms are also part of PD

Longitudinal studies have shown that posterior cortex involvement increases the risk of PDD, because PD patients with decreased semantic fluency and visual spatial function, decreased metabolism in the posterior cortex, and hippocampus and posterior cortex atrophy are more likely to develop PDD

Recently, a study published in the Journal of Radiology developed a prediction model based on machine learning, using only the cortical thickness of MRI , combined with clinical information, to assess the risk of PD and MCI patients’ conversion to dementia at an individual level , for PD patients Early diagnosis and disease monitoring provided strong support

This retrospective study included PD and MCI patients who underwent MRI examinations between September 2008 and November 2016

42 patients progressed to PDD (converters) (mean age, 71 years ± 6 [standard deviation]; 22 women), 75 patients did not progress to PDD (non-converters) (mean age, 68 years ± 6; 40 Women)

The image is used for the surface rendering image of the cortical thickness characteristics of Parkinson's disease dementia converter and non-converter classification .
ACG.
R=right anterior cingulate gyrus and accessory cingulate gyrus, ANG.
L=left angular gyrus, CAL.
R=right calcareous fissure and surrounding cortex, L=left, OLF.
L=left olfactory cortex, OLF.
R= Right olfactory cortex, ORBmid.
L=left middle frontal gyrus .
R=right olfactory cortex, ORBmid.
L=left middle frontal gyrus, orbit, PHG.
L=left parahippocampal gyrus, R=right, REC.
R=right straight gyrus, SOG.
R=right superior occipital gyrus .
 

The image is used for the surface rendering image of the cortical thickness characteristics of Parkinson's disease dementia converter and non-converter classification .

ACG.
R=right anterior cingulate gyrus and accessory cingulate gyrus, ANG.
L=left angular gyrus, CAL.

Although only should PDD predicting cortical thickness measured by MRI transformation still limitations, but the cortical thickness and clinical variables combined clinical PDD forecast PD and MCI patients at the individual level of significance

Original source

Na-Young Shin , Mirim Bang , Sang-Won Yoo ,et al .

Cortical Thickness from MRI to Predict Conversion from Mild Cognitive Impairment to Dementia in Parkinson Disease: A Machine Learning-based Model.
DOI: 10.
1148/radiol.

Na-Young Shin Mirim Bang Sang-Won Yoo ,et al 10.
1148/radiol.
2021203383 10.
1148/radiol.
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