Radiology: What are the special manifestations of brain iron content in the elderly with normal cognition?

As an important transition metal, iron plays an important role in the biological functions of the brain

As an important transition metal, iron plays an important role in the biological functions of the brain

The development of Quantitative Magnetic Sensitivity (QSM) MRI technology makes it possible to measure tissue iron content with high spatial resolution and high sensitivity non-invasively

Recently, a study published in the Journal of Radiology used QSM MRI technology and PET to explore the effects of brain tissue iron content and β-amyloid protein on the cognitive function of normal elderly people, to further understand and clarify the pathological basis of cognitive impairment in the clinic Provide imaging support

The subjects of this study were 150 elderly people with normal cognition (mean age 69 years ± 8 years [standard deviation]; 93 women)

Hippocampus brain iron content and overall cognitive composite scores negative correlation PET subgroup in hippocampus of iron content and episodic memory ( and visuospatial negative correlation score , and both the β- amyloid load independent of the iron content in brain tissue Negatively correlated with β-amyloid and overall cognitive function score

Figure episodic memory scores (A, B), executive function scores (C, D), visual space scores (E, F), language scores (G, H), and tissue sensitivity scores in all participants with normal cognitive function ( n = 150), PET group (n = 97) and β-amyloid negative participants (n = 75) hippocampal magnetic susceptibility values ​​of multiple linear regression model scatter plot

Figure episodic memory scores (A, B), executive function scores (C, D), visual space scores (E, F), language scores (G, H), and tissue sensitivity scores in all participants with normal cognitive function ( n = 150), PET group (n = 97) and β-amyloid negative participants (n = 75) hippocampal magnetic susceptibility values ​​of multiple linear regression model scatter plot

Table Voxel-based analysis results of the relationship between iron load and b-amyloid load in the PET group

Table Voxel-based analysis results of the relationship between iron load and b-amyloid load in the PET group

The results of this study indicate that the increase in iron content in brain tissue is related to the decline in cognitive function of the elderly with normal cognition, and has nothing to do with β-amyloid

Original source:

Lin Chen , Anja Soldan , Kenichi Oishi ,et al.

Lin Chen , Anja Soldan , Kenichi Oishi , et al.
Quantitative Susceptibility Mapping of Brain Iron and β-Amyloid in MRI and PET Relating to Cognitive Performance in Cognitively Normal Older Adults .
DOI: 10.
1148/radiol.
2020201603 10.
1148/radiol.
2020201603

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