Radiology: Whole brain dynamic contrast-enhanced MRI evaluation of patients with high-grade glioma

Dynamic Contrast Enhancement (DCE) MRI can evaluate neurovascular parameters by monitoring the enhancement pattern of tissue after injection of contrast agent
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These parameters can provide imaging markers for the tumor grade of patients with high-grade glioma and the early tumor response to anti-angiogenic therapy .

Brain lesions usually manifest as large-area spatial heterogeneity or thin-layer edge enhancement around the necrotic core; in addition, multifocal metastases may be visible throughout the brain .

Dynamic Contrast Enhancement (DCE) MRI can evaluate neurovascular parameters by monitoring the enhancement pattern of tissue after injection of contrast agent

Recently, he published in a journal Radiology study demonstrated a fully automated, high- spatial -resolution, full-DCE MRI brain scanning program , and according to brain swelling after treatment in patients with stable tumor tissue type of reference area multiple time points, The reproducibility of this program was evaluated, and imaging support was provided for the clinical evaluation of such patients
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In this study, the two DCE MRI methods of sub-Nyquist sampling were extended to automatically assess the vascular input function
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The images of 13 participants with high-grade gliomas (mean age ± standard deviation, 61 years ± 10 years; 9 women) were evaluated
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Figure is an example of a three-dimensional region of interest used to evaluate the reproducibility of tracer kinetic parameter estimates .

For each region of interest, shows three levels of a representative of the level .
Except for the nasal mucosa, all areas of interest are drawn on the opposite side of the lesion .

Figure is an example of a three-dimensional region of interest used to evaluate the reproducibility of tracer kinetic parameter estimates .

This study shows a fully automatic dynamic contrast enhancement (DCE) MRI reconstruction and modeling programs , and provides a high spatial and temporal resolution and full coverage brain
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Original source :

Yannick Bliesener , R Marc Lebel , Jay Acharya ,et al.
Pseudo Test-Retest Evaluation of Millimeter-Resolution Whole-Brain Dynamic Contrast-enhanced MRI in Patients with High-Grade Glioma

Yannick Bliesener R Marc Lebel Jay Acharya , et al.

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DOI: 10.

1148/radiol.
2021203628

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