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    Home > Biochemistry News > Biotechnology News > Radiometal Labeling of Antibodies and Antibody Fragments for Imaging and Therapy

    Radiometal Labeling of Antibodies and Antibody Fragments for Imaging and Therapy

    • Last Update: 2020-11-24
    • Source: Internet
    • Author: User
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    Monoclonal antibodies (MAbs) are highly selective agents for delivering radiation to tumors both for in vivo imaging (radioimmunoscintigraphy, RIS) and for therapy (radioimmunotherapy, RIT). Antibody-based radiopharmaceuticals can be labeled with iodine nuclides (
    123
    I for imaging,
    131
    I for therapy) or with metallic nuclides such as the γ radiation-emitting nuclides
    111
    In and
    199m
    Tc for imaging or the β

    particle-emitting nuclides
    90
    Y,
    67
    Cu, and
    188/186
    Re for therapy. The labeling of antibodies with three metallic nuclides is described here:
    67
    Cu for both imaging and therapy,
    99m
    Tc for imaging, and
    188/186
    Re for therapy.
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