Radiotherapy and Oncology: The brain network center associated with neurocognitive impairment in child subtentorial tumor survivors may be a therapeutic target

Two-thirds of children with brain tumors are diagnosed as subtentorial brain tumors
.

These patients usually suffer from neurocognitive impairment

Child diagnosis

The journal Radiotherapy and Oncology recently published an article reporting a cross-sectional study that assessed the relationship between the brain network topology, the functional role of network hubs (ie, highly connected areas), and the neurocognitive results of adult survivors of lower cerebellar tumors in childhood.
Relationship
.

The journal Radiotherapy and Oncology recently published an article reporting a cross-sectional study that assessed the relationship between the brain network topology, the functional role of network hubs (ie, highly connected areas), and the neurocognitive results of adult survivors of lower cerebellar tumors in childhood.
Relationship
.

Survivors of subtentorial tumors in children (n = 21: pilocytic astrocytoma (n = 8), ependymoma (n = 1) and medulloblastoma (n = 12)) and healthy controls (n = 21) Be recruited
.

Using multishell diffusion weighted MRI (multishell diffusion weighted MRI) to study the microstructure and topological structure of the white matter on the screen; using voxel-based methods, fixel-based analysis, and graph theory methods

Group comparison result (patient and control group)
.

Panel A depicts a comparison of voxel-based FA and ADC

Group comparison result (patient and control group)

The vulnerability of nodes to toxicity and the importance of intellectual results
.

Figure A: This figure shows the comparison of the node strength between the patient and the control group (the t statistic is represented by the size of the node), and the correlation between the node strength and the WAIS scale score (indicated by different colors)

The vulnerability of nodes to toxicity and the importance of intellectual results

The score anisotropy (FA) of patients with subtentorial tumors generally decreased.

The central area plays an important role in neurocognitive results.

Extensive microstructural changes were observed in the supratentorial brain area of ​​subtentorial tumor survivors

In children with subtentorial tumors, the central nervous system has a special vulnerability, which is very important for impaired neurocognitive abilities

Sleurs C, Jacobs S, Counsell SJ, et al.

Sleurs C, Jacobs S, Counsell SJ, et al.
Brain network hubs and cognitive performance of survivors of childhood infratentorial tumors [published online ahead of print, 2021 Jun 5].
Radiother Oncol .
2021;S0167-8140(21)06571-3 .
doi:10.
1016/j.
radonc.
2021.
05.
028 Sleurs C, Jacobs S, Counsell SJ, et al.
Brain network hubs and cognitive performance of survivors of childhood infratentorial tumors [published online ahead of print, 2021 Jun 5].
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