echemi logo
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > Ran protein is an "accomplice" to ovarian cancer transfer

    Ran protein is an "accomplice" to ovarian cancer transfer

    • Last Update: 2020-06-17
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit
    related findings were published in the journal Nature Communications under the title "Ran promotes sei-targeting and stabilization of RhoA to ovarian ovarian cancer cell invasion"Ran is a nuclear shuttle protein associated with cancer development and survival, primarily supporting transport within cells and between the nucleusThe team, led by Drs Anne-Marie Mes-Masson and DrDiane Provencher of the University of Montreal Hospital Research Center, found that in ovarian cancer cells, Ran is the "taxi" of RhoA, another protein in the cell membrane, which plays an important role in cell migration"In normal cells, RhoA can enter the cell membrane directly, but it can't in ovarian cancer cells,"DrDiane Provencher and DrAnne-Marie Mes-Masson,It must be connected to Ran before it can reach the cell membraneIt does require a 'taxi'," Mes-Masson explainsWithout RhoA, cancer cells lose the ability to move, migrate, and invade healthy tissue"
    Provencher said, "We've proven Ran to be a good target for treatmentOur research helps to understand when and in which patients our approach may be most beneficialSince healthy cells do not need Ran to move, we can 'target' cancer cells without touching healthy cells, and suppressing Ran is likely to be a successful strategy for other cancersnow, researchers have started to develop small molecules that inhibit Ran and test them in preclinical models they have developed to demonstrate that they can slow or eliminate cancerThey hope that these new drugs will be available clinically for the benefit of ovarian cancer patients in the futureSource:Addicted to Ran Ovarian, Cancer Cells Stop time timethe original title: Quick Glance Nature: This protein is an 'accomplice' to ovarian cancer transfer
    This article is an English version of an article which is originally in the Chinese language on and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to with relevant evidence.