related findings were published in the journal Nature Communications under the title "Ran promotes sei-targeting and stabilization of RhoA to ovarian ovarian cancer cell invasion"Ran is a nuclear shuttle protein associated with cancer development and survival, primarily supporting transport within cells and between the nucleusThe team, led by Drs Anne-Marie Mes-Masson and DrDiane Provencher of the University of Montreal Hospital Research Center, found that in ovarian cancer cells, Ran is the "taxi" of RhoA, another protein in the cell membrane, which plays an important role in cell migration"In normal cells, RhoA can enter the cell membrane directly, but it can't in ovarian cancer cells,"DrDiane Provencher and DrAnne-Marie Mes-Masson,It must be connected to Ran before it can reach the cell membraneIt does require a 'taxi'," Mes-Masson explainsWithout RhoA, cancer cells lose the ability to move, migrate, and invade healthy tissue"
Provencher said, "We've proven Ran to be a good target for treatmentOur research helps to understand when and in which patients our approach may be most beneficialSince healthy cells do not need Ran to move, we can 'target' cancer cells without touching healthy cells, and suppressing Ran is likely to be a successful strategy for other cancersnow, researchers have started to develop small molecules that inhibit Ran and test them in preclinical models they have developed to demonstrate that they can slow or eliminate cancerThey hope that these new drugs will be available clinically for the benefit of ovarian cancer patients in the futureSource:Addicted to Ran Ovarian, Cancer Cells Stop time timethe original title: Quick Glance Nature: This protein is an 'accomplice' to ovarian cancer transfer
