RBBP6 Derived Peptides: Anti-Ebola virus proteins are found in human cells.

The Ebola virus is a powerful virus that causes the onset of illness and high mortality rates in humans and primates.
the virus has been detected since 1976 for more than 40 years.
the ebola virus's devastation in Africa in 2014 and the 2018 outbreak again reported in Africa.
Despite the fact that an experimental Ebola vaccine has been given in African countries, it has to be admitted that there is still a lack of more robust and effective containment of the virus.
that's what the research is all about.
U.S. researchers said in a paper published in the journal Cell that they have found that a protein in human cells can help fight the Ebola virus, and that drugs that mimic the protein's function may one day be effective in treating the deadly disease.
like other viruses, the Ebola virus invades host cells and uses them to replicate them, but little is known to scientists about the specific routes and details of the virus's invasion during infection.
in the new study, Hetquist of Northwestern University's Feinberg School of Medicine worked with research partners at Georgia State University and the University of California, San Francisco, to explore the interactions between human proteins and Ebola virus proteins using pro-and-label purification mass spectrometry (AP-MS) techniques.
they not only found strong evidence of the interaction between the Ebola virus protein VP30 and the human protein RBBP6, but also identified 23 amino acid regions that bind RBBP6 to VP30.
further studies have shown that inhibiting RBBP6 stimulates virus transcription and accelerates replication of the Ebola virus, while stimulating RBBP6 to express more fully will effectively inhibit Ebola virus replication and prevent viral infection.
Hurtquist points out that viruses evolve to bypass the body's immune defenses, and that human cells, in turn, develop defense mechanisms against viruses, a long-running evolutionary competition.
special defense mechanism sourcing human development points the way for the development of targeted treatments.
their new research shows that targeted biologics have great potential in the fight against the Ebola virus, and that RBBP6-derived peptides may be effective in suppressing Ebola virus infection.
their ultimate goal is to respond to outbreaks of the Ebola virus by mimicking the RBBP6 protein and developing small molecule drugs that have easier access to human cells.
Source: Science Daily.