Reactions that may produce hazardous products (by-products) (1)

It is not only necessary to pay attention to the main reaction and the main product, but also to determine whether energy-rich or toxic by-products will be generated during the reaction process or post-processing.

Some energy-rich or toxic by-products have their own unique formation mechanism, which requires careful judgment.

1.

example 1

Application process: Dissolve reaction substrate A (150.

Remarks: This is a nucleophilic addition reaction of nitromethane with aldehyde groups under alkaline conditions

Before amplification, it is necessary to verify whether there is nitroacetaldoxime produced, if so, what is the amount produced, and whether it is accompanied in the product or in the mother liquor during extraction, and safety assessment is required

Example 2

Application process: Add dimethyl sulfoxide (6.

Example 3

Application process: Dissolve 1200g substrate A (1.

Remarks: ①Serious explosions occurred in this type of reaction during post-treatment and rotary steaming; ②After the reaction, add water directly, neutralize the excess NaOH with acid, adjust the pH to 7.

Related links: Phosphorus oxyhalides and reactions involving phosphorus halides