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Recombinant human GM-CSF in the treatment of COVID-19 hospitalized patients, the SARPAC clinical trial reached the primary endpoint of improved lung function

 Last Update: 2021-03-20
 Source: Internet
 Author: User

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Pharmaceutical company Partner recently announced the latest results of the SARPAC study, which aims to evaluate the effectiveness and safety of yeast-derived recombinant human GM-CSF Leukine® (sargramostim) in the treatment of COVID-19 hospitalized patients.

COVID-19

The results showed that compared with the standard of care (SOC) alone, the patient’s oxygenation was significantly improved after five days of combined treatment with inhaled sargramostim and SOC.

54% of patients in the argramostim and SOC combination treatment group improved in oxygenation (measured by alveolar artery oxygen gradient, defined as at least 33% higher than baseline), while 26% of patients in the SOC alone treatment group improved in oxygenation (p = 0.

These findings indicate that sargramostim does not aggravate or induce a cytokine storm, but can avoid it.

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