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    Home > Active Ingredient News > Infection > Recommended by WHO, IVD domestic replacement has new achievements in the field of tuberculosis diagnosis

    Recommended by WHO, IVD domestic replacement has new achievements in the field of tuberculosis diagnosis

    • Last Update: 2022-04-18
    • Source: Internet
    • Author: User
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    The COVID-19 pandemic has had a huge impact on TB control efforts


    Faced with the complex situation of tuberculosis prevention and control under the new situation, WHO has put forward a series of suggestions and measures on how to do a good job in tuberculosis prevention and control in the context of the new crown pneumonia pandemic


    WHO has put forward a series of recommendations and measures on how to do a good job in tuberculosis prevention and control in the context of the new crown pneumonia pandemic

    What we are proud of is that the latest WHO policy statement " Use of alternative interferongamma release assays for the diagnosis of TB infection " in 2022 focused on evaluating and recommending TB-IGRA developed and produced by Wantai Bio in China, which is also the only one mentioned and described in detail.


    WHO policy statement Use of alternative interferongamma release assays for the diagnosis of TB infection Use of alternative interferongamma release assays for the diagnosis of TB infection

    The article pointed out that, based on published big data analysis, comprehensive consideration of sensitivity, specificity and other indicators, the performance of Beijing Wantai TB-IGRA is comparable to the performance of IGRA recommended by WHO for the detection of tuberculosis infection.


    Based on the analysis of published big data and comprehensively considering indicators such as sensitivity and specificity, the performance of Beijing Wantai TB-IGRA is comparable to that of IGRA recommended by WHO for the detection of tuberculosis infection.


    As we all know, China is a country with a high burden of tuberculosis, and the annual number of new patients has always been at the forefront of the world


    In order to better use IGRA to serve the prevention and treatment of tuberculosis, the Chinese tuberculosis expert group, based on the rich experience accumulated in domestic clinical applications, published the "Mycobacterium tuberculosis γ-interferon release test" suitable for China's national conditions after the WHO updated the document.


    The "Expert Opinion" clearly pointed out that IGRA has obvious advantages compared with the traditional tuberculin skin test: it has high specificity, is not interfered by BCG vaccination and most NTMs, and uses a single threshold as the positive judgment standard, which is more suitable for epidemic detection.


    Can supplemental antigen combinations or proposed derived indicators differentiate LTBI from ATB?

    Can supplemental antigen combinations or proposed derived indicators differentiate LTBI from ATB? Can supplemental antigen combinations or proposed derived indicators differentiate LTBI from ATB?

    IGRA mainly uses ESAT-6 and CFP-10 recombinant proteins or mixed polypeptides as specific antigens


    Is IGRA suitable for ascites and cerebrospinal fluid?

    Is IGRA suitable for ascites and cerebrospinal fluid? Is IGRA suitable for ascites and cerebrospinal fluid?

    The "Expert Opinion" pointed out that the enzyme-linked immunospot assay (ELISPOT) is mainly based on the detection of peripheral blood, and the interpretation standards of pleural effusion and cerebrospinal fluid ELISPOT detection need to be further determined.


    Can IGRA be used to monitor the efficacy of anti-tuberculosis treatment?

    Can IGRA be used to monitor the efficacy of anti-tuberculosis treatment? Can IGRA be used to monitor the efficacy of anti-tuberculosis treatment?

    The "Expert Opinion" pointed out that the tuberculosis-specific IFN-γ response decreased during the treatment of tuberculosis patients, but the individual responses were very different.


    At present, due to its high sensitivity and specificity, the IGRA method has been widely used and recommended by more than 30 countries and regions in the world, including the United States, China, Japan, Switzerland, and South Korea, to help prevent and control tuberculosis around the world




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