Recovery and purification of pharmaceutical intermediates by continuous countercurrent ion exchange or fractionation

The extraction of traditional Chinese medicine is an important part of the production process of traditional Chinese medicine, and the automation of the extraction process is an important part of the modernization of traditional Chinese medicine industry In this paper, the design of automatic control system for Chinese medicine extraction production line is discussed with readers [Key words] extraction of traditional Chinese medicine; control system i characteristics of extraction production process of traditional Chinese medicine in process industry, batch production process and continuous production process are widely used Batch production process, also known as batch production process, belongs to the production process of producing a certain amount of products according to a given formula The mass production process is generally used in the extraction production of traditional Chinese medicine, that is, to produce a certain amount of traditional Chinese medicine extract according to a given formula The production formula of traditional Chinese medicine extraction mainly includes: products and raw material components; required production equipment; required production operations (such as heating, stirring, precipitation, etc.) 2、 Batch production process control technology 1 Batch production process control can be divided into two parts: real-time control layer and production management layer The real-time control layer can include: real-time production management, sequence control, discrete / regulation control, process chain, safety chain, process I / O; production management layer can include: Production Planning, production scheduling, formula management, etc 2 Three, design the computer control system of traditional Chinese medicine extraction According to the current situation of our country, traditional Chinese medicine enterprises generally divide the integrated intermittent control system into two parts, namely the production management part (e.g ERP) and the real-time control part The computer control system of traditional Chinese medicine extraction discussed here refers to the real-time control part, i.e program intermittent control system 1 Design the computer control system of traditional Chinese medicine extraction, which can be selected N remote computer control of production process, monitoring n flexible, rapid, accurate and consistent operation and control N shorten the production cycle of each batch of products Optimize the control, improve the utilization rate of raw materials, energy and equipment, reduce the waste rate n computer control parameter management n computer production process data storage, query and report printing n process chain n reliable security chain control n alarm n electronic signature 2 typical control system scheme 2.1 typical traditional Chinese medicine extraction process and traditional Chinese medicine extraction production line process: Herbs > washing > drying > chopping > water extraction three times > filtration > storage > vacuum concentration > > spray > granulation > > Paste > low temperature dry > > concentrate > > precipitation > separation > > decompression concentration > precipitation > extraction of effective ingredients modern Chinese medicine preparation process: medicinal material > washing > drying > chopping > water extraction three times > filtration > resin adsorption > Water washing > elution > decompression concentration > alcohol precipitation > filtration > decompression concentration > low temperature drying or spray drying > the finished Chinese medicine extraction line can be generally designed as a dedicated single production line, dedicated multi production line, reconfigurable and multi production line The production line usually adopts two layout methods, assembly line layout and partition layout Assembly line layout is adopted, process and equipment layout are clear at a glance, while sub regional layout saves space 2.1.2 typical extraction equipment of traditional Chinese medicine and its basic operation control The basic operation control of the extraction tank mainly includes the following contents: leakage test control, quantitative addition of solvent, manual feeding, temperature rise control, constant temperature timing, boiling timing, timing cycle, timing mixing, discharge control, alcohol reflux, aromatic oil recovery, slag discharge control, back blowing control, direct steam control, cleaning control, boiling, alarm and safety interlock 2.1.2.2 external circulation single effect evaporator the external circulation single effect evaporator is composed of heater, evaporator, separator, etc it is mainly used for alcohol recovery and concentration in the fields of pharmacy, plant medicine, chemical industry, food, dairy products, etc., and also for material liquid concentration Basic operations include: quantitative feeding, heater steam pressure / temperature control, evaporator vacuum control, cooling water flow detection, cooling water temperature detection, density detection and paste collection control, automatic defoaming, liquid level control, condensate discharge or solvent recovery control, cleaning control, boiling tank control, etc Double effect or multi effect concentrator, composed of two or more heaters, evaporators, separators, etc., is suitable for the concentration of feed liquid in the fields of pharmacy, plant medicine, chemical industry, food, dairy products, etc Basic operations include: quantitative feeding, heater steam pressure (temperature) control, evaporator end effect vacuum control, cooling water flow detection, cooling water temperature detection, feeding control, density detection and paste collection control, automatic defoaming, liquid level control, condensate discharge control, cleaning control, boiling tank control, etc The agitation sedimentation tank is mainly used for alcohol precipitation of traditional Chinese medicine, food, health products, chemical industry, etc The basic operation includes: feeding, feeding ethanol according to the proportion, mixing, settling timing, cooling control, discharging, slag discharging and cleaning 2.1.2.4 solvent configuration tank control the solvent configuration tank is mainly used to configure alcohol of specified concentration The basic operations include: concentration detection of refined alcohol, concentration detection of dilute ethanol, calculation of the addition amount of refined alcohol, diluted ethanol and water according to the required concentration and configuration amount, addition of refined alcohol, diluted ethanol and water according to the calculation amount, circulation, temperature control, concentration detection Source: modern Chinese medicine network