February 4, 2021 // -- A recent article published in the international magazine Redox Biology entitled "Hypochlorite-induced aggregation of fibrinogen underlies a novel antioxidant role in In a study by Blood plasma, scientists from Flinders University and others found that a known coagulant protein, fibrinogen, may have new anti-inflammatory effects, and that the findings could help develop new treatments for kidneys, heart and other common diseases. in the
article, the researchers described how fibrinogens act as a protective agent against hypochlorite, a special chemical produced by the body during inflammation, and how it plays a key role in the plasma as a class of antioxidants.
My Wyatt says that when interacting with hychlorates, fibrinogens form very large aggregates so that they don't damage the body's cells like the chlorate-modified albumin and exacerbate the symptoms of kidney and heart disease.
photo source: CC0 Public Domain Although fibrinogens are not as rich as the main protein albumin in the blood, they are more likely to react with hychlorates in the body, where the accumulation of perchlorate-modified albumins Inducing an injury response in the patient's body, however, the fibrinogen modified by hychlorate appears to be harmless to the body's health, and the study found that it may eventually be available to help design new therapies to block the harmful effects of the chlorate-modified albumin. In the
study, researchers pinpointed the behavioral mechanisms of these different protein molecules, which they were able to use to block the disease-inducing effects of perchlorate-modified albumins, and they also mapped the normal functioning of protein molecules and the changes in their function when protein molecules were impaired by biological factors such as hychlorates.
findings are also expected to help scientists find new biomarkers that indicate a variety of inflammatory diseases.
original source: Noralyn Mañucat-Tana, Rafaa Zeineddine Abdallah, Harsimran Kaur, et al. Hypochlorite-induced aggregation of fibrinogen underlies a novel antioxidant role in blood plasma, Redox Biology (2020). DOI:10.1016/j.redox.2020.101847