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▎Editor of WuXi AppTec's content team After being infected with the new crown, different people will have different reactions.
Some people can be completely "asymptomatic", while others will have a fatal inflammatory reaction.
Today, "Cell" magazine published a paper online and found an old drug that has been approved by the US FDA.
It is expected to have a second spring and make the new crown no longer so terrible.
The researchers pointed out that under the induction of the virus, the immune system will produce a large number of chemokines and cytokines to recruit white blood cells to fight infection.
However, if the immune system is too active and the recruitment of white blood cells is excessive, it will cause severe inflammation, resulting in tissue damage, organ failure, and even death of the patient.
Therefore, if these inflammatory reactions can be alleviated, it is expected to improve the clinical prognosis of patients.
▲Strong inflammatory response is an important cause of severe illness and even death in patients with new crowns (picture source: reference [1]) In this study, scientists used multi-dimensional analysis and found that a protein called TOP1 would be infected in new crowns Activates the expression of inflammatory genes.
Interestingly, the US FDA has previously approved a drug called Topotecan, which can inhibit TOP1, thereby inhibiting these inflammatory genes.
In the hamster model, this drug can indeed inhibit the inflammatory response induced by infection.
In the mouse model, the researchers also found that treatment with Topotecan even 4 days after infection can reduce mortality.
These results also support the inhibition of TOP1, which is expected to become a potential treatment for severe new coronary diseases.
Considering that the cost of such drugs and their derivatives is not high in most countries and regions, this adds to the significance of the discovery.
▲The old drug Topotecan reduces inflammation by inhibiting TOP1 (picture source: Reference [1]) "Our work shows that TOP1 inhibitors can be used with new drugs and become a valuable global strategy in the treatment of severe new coronary diseases," this research The corresponding author Professor Ivan Marazzi said, "Especially considering that this drug has been approved by the FDA, and the price is not expensive, there are generic drugs in the world.
This also makes these drugs have good accessibility and can be developed Both countries and developed countries are used immediately.
"In the future, researchers plan to start clinical trials to evaluate the potential of the drug in humans.
We look forward to hearing more positive news.
Reference: [1] Jessica Sook Yuin Ho et al.
, (2021), TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation.
, Cell, DOI: https://doi.
org/10.
1016/j.
cell.
2021.
03.
051[2] Anti-inflammatory drug protects against lethal inflammation from COVID-19 in animal models, Retrieved March 30, 2021, from.
php
Some people can be completely "asymptomatic", while others will have a fatal inflammatory reaction.
Today, "Cell" magazine published a paper online and found an old drug that has been approved by the US FDA.
It is expected to have a second spring and make the new crown no longer so terrible.
The researchers pointed out that under the induction of the virus, the immune system will produce a large number of chemokines and cytokines to recruit white blood cells to fight infection.
However, if the immune system is too active and the recruitment of white blood cells is excessive, it will cause severe inflammation, resulting in tissue damage, organ failure, and even death of the patient.
Therefore, if these inflammatory reactions can be alleviated, it is expected to improve the clinical prognosis of patients.
▲Strong inflammatory response is an important cause of severe illness and even death in patients with new crowns (picture source: reference [1]) In this study, scientists used multi-dimensional analysis and found that a protein called TOP1 would be infected in new crowns Activates the expression of inflammatory genes.
Interestingly, the US FDA has previously approved a drug called Topotecan, which can inhibit TOP1, thereby inhibiting these inflammatory genes.
In the hamster model, this drug can indeed inhibit the inflammatory response induced by infection.
In the mouse model, the researchers also found that treatment with Topotecan even 4 days after infection can reduce mortality.
These results also support the inhibition of TOP1, which is expected to become a potential treatment for severe new coronary diseases.
Considering that the cost of such drugs and their derivatives is not high in most countries and regions, this adds to the significance of the discovery.
▲The old drug Topotecan reduces inflammation by inhibiting TOP1 (picture source: Reference [1]) "Our work shows that TOP1 inhibitors can be used with new drugs and become a valuable global strategy in the treatment of severe new coronary diseases," this research The corresponding author Professor Ivan Marazzi said, "Especially considering that this drug has been approved by the FDA, and the price is not expensive, there are generic drugs in the world.
This also makes these drugs have good accessibility and can be developed Both countries and developed countries are used immediately.
"In the future, researchers plan to start clinical trials to evaluate the potential of the drug in humans.
We look forward to hearing more positive news.
Reference: [1] Jessica Sook Yuin Ho et al.
, (2021), TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation.
, Cell, DOI: https://doi.
org/10.
1016/j.
cell.
2021.
03.
051[2] Anti-inflammatory drug protects against lethal inflammation from COVID-19 in animal models, Retrieved March 30, 2021, from.
php
