Regeneron "cocktail" therapy can effectively protect animals and speed up the elimination of viruses

Regenerative Meta has extensive experience in developing a medium-range antibody therapy for infectious diseases, and its antibody "cocktail" therapy for Ebola virus infection has shown excellent therapeutic results in clinical trials.
the antibody "cocktail" therapy, called REGN-CoV2, consists of two kinds of meso-antibodies that bind to different bits in the critical bind binding domain (RBD) of the new coronavirus pyroid protein.
in two papers published in the journal Science on Tuesday, the regenerative team found that biantibodies not only act effectively against a single antibody, but also prevent the virus from developing resistance through mutations under the selected pressure of a single antibody therapy.
In this study, researchers further explored the potential of REGN-CoV2 to treat and prevent new coronavirus infections in the rhesus monkey model in a structural model in which two antibodies bind to RBD, dark blue as RBD, yellow/red and green/cyan as two different median antibodies (Photo Source: Reference: Reference 2).
for preventive treatment, the researchers injected six rhesus monkeys with a dose of 50 mg/kg of REGN-CoV2, and then tested them for poison three days after the injection.
results showed that a large number of newly replicated new coronaviruses appeared in nasal swabs and anti-bubble syringe (BAL) samples from six monkeys injected with placebo injections, while REGN-CoV2 almost completely blocked the virus's replication in nasal swab samples and BAL samples, and significantly accelerated the removal of the new coronavirus.
even though the researchers increased the dose by 10 times, REGN-CoV2 showed good preventive results.
in both nasal swab samples and alfurch dosing fluid (BAL) samples, REGN-CoV2 (right) significantly reduced sgRNA levels associated with the newly replicated virus (Photo Source: Reference 1) In therapeutic experiments, researchers injected REGN-CoV2 a day after poisoning the monkeys, and the results showed that animals treated with REGN-CoV2 also improved the speed at which they removed the new coronavirus.
because the new coronavirus infection in the rhesus monkey model only leads to short-lived viral replication and mild clinical symptoms, the researchers decided to repeat the REGN-CoV2 experiment in the golden hamster model.
golden hamsters develop very high viral loads in the lungs after contracting the new coronavirus infection, severe lung pathology and rapid weight loss.
model may better simulate severe COVID-19 patients.
the results showed that in this model, different doses of preventive REVEN-CoV2 injections two days prior to receiving the poison could significantly reverse the weight loss caused by the new coronavirus infection.
and seven days after the attack, the viral load on the animal's lungs dropped significantly.
REGN-CoV2 in the golden hamster model, as a preventive means to reverse the weight loss of animals caused by new coronavirus infections (Photo source: Reference 1)) The researchers note in the discussion of the article that REGN-CoV2, as a preventive therapy, almost completely blocks replication of the new coronavirus in upper and lower respiratory tract samples in the rhesus monkey model.
shows its potential to prevent new coronavirus infections in addition to treating them.
two days before the launch, Johnson and Johnson released the results of its experiments in the same rhesus monkey model for Ad26.COV2.S, a new coronavirus vaccine.
REK-CoV2 as a preventive therapy in controlling the replication of the new coronavirus is comparable to the performance of Ad26.COV2.S.
In early July, Regenerative Meta announced that REGN-CoV2 had shown good safety characteristics in Phase 1 clinical trials, and that two Phase 3 clinical trials had been launched to evaluate the effectiveness of this medium-antibody "cocktail" therapy in preventing and treating new coronavirus infections.
reference: s1. Baum et al., (2020). REGN-COV2 antibody cocktail prevents and treats SARS-CoV-2 infect in rhesus macaques and hamsters. bioRxiv, ( 2 ) Hansen et al., (2020). Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail. Science, DOI: 10.1126/science.abd0827 Original title: New ways to prevent new crowns! Regenerative "cocktail" therapy can effectively protect animals and speed up the removal of viruses.