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    Home > Biochemistry News > Biotechnology News > Regulating fatty acid intake may contribute to mood changes in people with bipolar disorder

    Regulating fatty acid intake may contribute to mood changes in people with bipolar disorder

    • Last Update: 2021-09-29
    • Source: Internet
    • Author: User
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    Can specific dietary guidelines help people with bipolar disorder better manage their health? Maybe one day, according to a new study by researchers at the Pennsylvania State University School of Medicine
    .
    The results of clinical trials have shown that a diet designed to change the levels of specific fatty acids consumed by participants may help reduce the variability of patients' moods

    .

    Bipolar disorder affects 2.
    4% of the population and is a mental health condition in which individuals experience periodic and abnormally elevated and/or depressive emotional states

    .
    During an acute attack, the part of the brain that controls emotions is not active, leading to a manic high or a depression

    .
    Researchers are looking for ways to help patients relieve symptoms between episodes, which include pain, anxiety, impulsivity, and irritability

    .

    "As clinicians, we understand that if we can help patients better control these symptoms between episodes, we can help reduce the number of times they relapse into acute episodes," Pennsylvania State University Health Milton S.
    Hershey Medical Said Dr.
    Erica Sanders, Professor of Shively-Tan, the Dean of the Department of Psychiatry and Behavioral Health of the Center

    .
    "The goal of our trial is to see whether specific dietary interventions can help patients with emotional changes between episodes

    .
    "

    Saunders and her colleagues devised a diet to change the levels of certain polyunsaturated fatty acids—many foods contain this nutrient—that participants consume when participating in the routine treatment of bipolar disorder, including Mood stabilizing drugs
    .
    Previous research has shown that drugs used to treat bipolar disorder change the way the body breaks down or metabolizes fatty acids

    .
    The byproducts of this process activate different parts of the immune system, including other chemical processes that affect the body's perception of pain, a common symptom reported by patients with bipolar disorder

    .

    The researchers hypothesized that by changing the type and amount of fatty acids ingested, the body will produce metabolites with specific purposes, such as reducing pain or inflammation
    .
    The experimental diet reduced the intake of omega-6 fatty acids by restricting red meat, eggs and certain fats, and increased the intake of omega-3 fatty acids by adding flaxseed and fatty fish such as tuna and salmon

    .
    In order to keep the participants from knowing which group they belonged to, the research team provided participants with specific meal plans, including instructions on how to prepare food, unlabeled cooking oil, specially prepared snacks and baked products

    .

    More than 80 patients with bipolar disorder participated in the diet consultation and received specific foods over a 12-week period
    .
    They complete surveys on emotions, pain, and other symptoms on mobile devices twice a day

    .
    Throughout the study, participants also performed blood tests so that the researchers could measure fatty acid levels and the effects of food on their bodies

    .
    According to the researchers, this experimental diet improved mood variability in patients with bipolar disorder

    .
    The results of the study were published in the journal Bipolar Disorder

    .

    "At present, we cannot recommend this diet to patients with bipolar disorder, although we have found that this diet is safe," Saunders said, noting that follow-up studies are needed
    .
    "This well-designed nutritional plan shows the hope of regulating emotions between mania and depressive episodes, but we are not sure whether it will be widely adopted because it will be a challenge for patients to follow this strict plan

    .
    "

    In the future, the research team will continue to evaluate how fatty acid metabolites affect pain in patients with bipolar disorder
    .
    Sanders said that by repeating this research, they hope to provide patients with bipolar disorder with reasonable and scientific dietary recommendations, which will be easier to implement in their daily lives

    .

    Sanders said: "This diet is not suitable for people with bipolar disorder, they are experiencing acute, severe depression or mania
    .
    " "On the contrary, our goal is to develop solutions to help patients better long-term Manage their symptoms, including pain

    .
    "

    DOI

    10.
    1111/bdi.
    13112

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