Remembering Zhao Zhendong: Scientific exploration must have a spirit of studying to the end

in the fight against the new crown pneumonia epidemic, he fought for more than 200 days in a row, accumulated a disease, unfortunately died.
His name is Zhao Zhendong, a former head of the vaccine research and development team of the Joint Prevention and Control Mechanism of the State Council, and a researcher at the Institute of Pathogen Biology of the Chinese Academy of Medical Sciences, known as the "guardian of the new crown vaccine".
16, 2020, at 8 p.m., Zhao Zhendong returned to Beijing from Changsha after attending an academic conference and fell at the exit of Terminal T3 of the Capital Airport. The day before, he was in Wuhan to participate in the new crown inactivated vaccine production workshop biosecurity joint inspection. In the early hours of September 17th, he died quietly at the age of 53.face of the sudden outbreak of new coronary pneumonia, Zhao Zhendong immediately put into vaccines, antibodies and other outbreak prevention and control urgently needed basic research. He led the Beijing Municipal Science and Technology Commission's new coronavirus pneumonia prevention and treatment of emergency science and technology support key projects, completed the screening of anti-new coronavirus drugs, built a new coronavirus replication evaluation platform system, in order to promote China's vaccine research and development and emergency use has done a lot of basic work.
On February 15, 2020, Zheng Zhongwei, head of the vaccine research and development team of the Joint Prevention and Control Mechanism of the State Council and director of the National Health and Health Commission's Medical and Health Science and Technology Development Research Center, found Zhao Zhendong and said that a scientist who understands vaccine research and development is needed to serve as the technical team leader of the vaccine research and development team, but can not directly participate in vaccine research and development, and can only help the 12 research and development units of 5 technical routes to come up with ideas and find ways to share their ideas free of charge.
"I'm going to be on it again! "Two days later, Zhao Zhendong put down his job and served as the technical team leader of the special class. "Now is the time to fight, to race against time," he said. "For six months, he never had a day off, day and night, never a complaint.at the beginning of the
vaccine research and development course, Zhao Zhendong and related staff intensive research, two days to visit Beijing Science and Technology,
Microbiology Institute, Chinese biology and other research and development units in Beijing New Crown Vaccine, put forward a number of important recommendations to solve the difficulties in research and development. He also summarized the progress of research on the new coronavirus vector vaccine, nucleic acid vaccine, antibody and so on, analyzed in depth the advantages and disadvantages of different vaccine research and development technology routes at home and abroad, and actively made suggestions for the research and development of the new crown vaccine in China.
While competing for the second to become a good vaccine research and development assistant, Zhao Zhendong devotes himself to the preparation of the General Requirements for Biosecurity in vaccine production workshops, and he has also completed a joint biosurance assessment by China Pharmaceuticals Beijing, Wuhan and Koxing. Among them, the suggestions of spiral improvement of inoculation bottles and identification of reactor tank connectors have been adopted by enterprises to help enterprises clarify the operating technical specifications and play an important role in the production of the new crown vaccine."He was born for scientific research, love scientific research to the point of obsession. He has been living in his world, which is the study of infectious immunology. Zhao Zhendong's wife, Wang Bin, said.
Wang Bin is the inspector of the Disease Prevention and Control Bureau of the National Health and Safety Commission. She said that many people find scientific research boring, but Zhao Zhendong sitting on the sofa reading literature, change papers, three or four hours without moving. The house was full of literature, and sofas, bedsides and even bathrooms were everywhere. The joy of solving scientific problems and the joy of making experimental progress always attract him to explore...
" Our home is far from Zhao Zhendong's unit, four hours a day back and forth, but he rarely shout tired. He seized his time on the subway to read the literature. Wang Bin said the habit has allowed him to master a large number of international cutting-edge technology and the latest achievements.
Zhendong is the "more human" in the lab. In order to speed up the progress of the experiment, he was always the first to go to the lab and the last to leave. One of his students said: "The results of our experiment are very forward-looking, but Mr. Zhao is more demanding and always wants to do more." "One of the findings of Zhao Zhendong's team is to build a new coronavirus replication subsyscil, providing a safe and effective tool for the screening and evaluation of antiviral drugs. This means that experiments that had previously had to be carried out in bioseterial level III laboratories can now be carried out in bios security level II laboratories, providing an important experimental system and technical support for the development of antiviral drugs for the new coronavirus.
addition to the five technical routes, Zhao Zhendong also led the research team on the new coronavirus and respiratory virus multi-price vaccine with the Newtown disease virus as the carrier. This viral vector vaccine can produce specific neutral antibodies by dropping nose immunity, allowing the body to obtain immune protection.
in the animal experiment phase, Zhao Zhendong came home from work and always called the team to discuss the problem. His wife advised him: "The country has so many vaccine research and development of the top team, you do not hit the south wall, even if made, transformation and application of the problem how to crack?" Zhao Zhendong responded: "This is also a new vaccine research and development ideas and processes, these basic work will be helpful in the future to deal with new infectious diseases." " Zhao Zhendong's apothetism, truth-seeking, always adhere to the first line of scientific research. He is unique in the field of infection immunology, and his research has been published in high-level professional journals. He has received the Outstanding Achievement Award for Scientific Research in Higher Education Institutions of the Ministry of Education and has made numerous reports at international conferences such as hepatology and cell autophagy.
, an assistant researcher at the Institute of Pathogen Biology of the Chinese Academy of Medical Sciences, recalls that Zhao Zhendong has been reading literature for more than a decade, never tired of pursuing new knowledge. Zhao Zhendong spends almost all his time on scientific research, enjoying him and working tirelessly, Wang said.
"We have a lab WeChat group, and Mr. Zhao often shares the literature he sees with everyone so that everyone can learn." In this WeChat group, we also know the rhythm of Mr. Zhao's work: sometimes we receive documents late at night, sometimes we receive documents at four or five in the morning..." Wang recalls.
, an associate professor at The Capital Medical University, said Zhao Zhendong has always stressed that scientific research should be serious and rigorous. He places great demands on the student's professional foundation and academic ability, and each conclusion is confirmed by at least five to 10 experiments.
Zhao Zhendong once told the students, "I will not criticize you for the failure of the experiment, because scientific research is the process of exploration." However, if there is a problem with the attitude of doing scientific research, I will not tolerate it. Scientific exploration must have a spirit of studying to the end, do one thing to do the best. I don't care what kind of last article I send, I want you to stick to the spirit of scientific research. On
30, 2020, the Beijing Concord Medical College of the Chinese Academy of Medical Sciences held a report on Zhao Zhendong's advanced deeds. Wang Chen, vice president of the Chinese Academy of Engineering and president of the Beijing Concord Medical College of the Chinese Academy of Medical Sciences, said Zhao Zhendong is a scientist who does not care about personal gain or interest, dares to offer different opinions, has no heart, and has the style of a scholar. From the fight against SARS, H1N1 influenza, Ebola, to the fight against the new crown pneumonia epidemic, he is on the front line, worthy of the vast number of scientific researchers to learn.
Zhao Zhendong is gone, he left behind not only scientific research results, but also admirable spirit of scientists ...