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| Repairing protein production errors can extend lifespan |
Science and Technology Daily, Beijing, September 14 (Intern reporter Zhang Jiaxin) A new study conducted by researchers from University College London and the Medical Research Council (MRC) London Institute of Medical Sciences in simple model organisms found that it reduces protein synthesis Natural errors in (production) can improve health and extend life
.
The new discovery, published on the 14th in the internationally renowned journal "Cell Metabolism", for the first time proved the direct link between the reduction of protein errors and lifespan
"DNA mutations can cause cancer, and this is also considered to be one of the potential causes of aging
.
" The lead author of the study, University College London Cancer Institute Dr.
In this study, the scientists studied an evolutionary "super-precision" mutation called RPS23 K60R, which was found in the ribosome (the protein production factory of the cell) of hyperthermophilic archaea.
A single-celled organism that can survive at extremely high temperatures
.
Through genome editing, the scientists designed a metazoan (a general term for all other animals except protozoa) ribosomes to carry the same mutations (single amino acid changes) as hyperthermophilic archaea.
Its effect on protein synthesis is replicated in simple model organisms such as flies
.
The research team observed that when the organism has fewer protein errors, the organism becomes heat-resistant and lives longer
.
Researchers say that the process of making proteins is not without errors-ribosomes can also make mistakes
.
Studies have shown for the first time that changing an amino acid in the ribosome decoding center can reduce protein synthesis errors, improve the body's ability to resist stress and prolong life
In addition to the redesigned ribosome, the researchers found that some drugs approved for use in the human body can also reduce errors in the protein
.
Interestingly, these drugs, including rapamycin, tolin and trametinib are also known anti-aging drugs
The co-corresponding author of the study, Professor Felipe Cabrero of MRC's London Institute of Medical Sciences, said: "This is the first time a study has been conducted in a metazoan organism and has revealed that fewer errors in protein can prolong health and lifespan.
; It is expected that in the future we will extend the results of research on yeast, worms and flies to mammals, which may lead to the emergence of new therapies to improve the health of the elderly
.
"
