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    Home > Active Ingredient News > Study of Nervous System > Research by a team of Chinese scientists: High blood pressure is diagnosed around the age of 40, and the risk of dementia is the highest!

    Research by a team of Chinese scientists: High blood pressure is diagnosed around the age of 40, and the risk of dementia is the highest!

    • Last Update: 2021-10-21
    • Source: Internet
    • Author: User
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    In the past, hypertension was usually a "proprietary" disease of the elderly
    .

    Nowadays, with the continuous improvement of living standards and the deterioration of diet and living habits, hypertension has spread among middle-aged people, and there are more and more patients with early-onset hypertension
    .

    Recently, the largest study to date on global hypertension trends published in the "Lancet" found that in the past 30 years, the number of adults aged 30-79 with hypertension has increased from 6.
    5 Billion increased to 1.
    28 billion, of which more than 700 million people do not know that they have high blood pressure
    .

    As we all know, hypertension is an important risk factor for cardiovascular and cerebrovascular diseases.
    It can significantly increase the incidence of complications such as stroke (stroke), coronary heart disease, heart failure, end-stage renal disease, and male erectile dysfunction
    .

    Not only that, premature hypertension can also lead to a significant increase in the risk of dementia
    .

    Recently, in a study published in the journal Hypertension under the Journal of the American Heart Association, a research team led by Guangdong Provincial People’s Hospital found that individuals diagnosed with high blood pressure between the ages of 35 and 44 are related to the whole brain and gray matter.
    It is related to the smaller white matter volume and the highest risk of dementia
    .

    The study shows that early middle age is a critical period for the prevention and treatment of hypertension to prevent dementia or brain damage
    .

    Previous studies have shown that middle-aged hypertension is an important factor in determining brain volume
    .

    However, the effect of age at onset of hypertension on this link is still poorly understood by researchers
    .

    It is estimated that middle-aged hypertensive patients account for 1.
    9% of global dementia
    .

    Previously, in a study published in "Nature Communications", researchers from the University of Oxford in the United Kingdom confirmed that hypertension and diabetes affect the brain in subtle ways like boiled frogs in warm water, and this effect occurs in middle age.
    Has appeared
    .

    In this study, the researchers used data from participants in the UK Biobank to compare the brain volume magnetic resonance imaging (MRI) measurement results of two large cohorts of adults, of which 11399 participated The participants were divided into 5 groups (<35 years old, 35 to 44 years old, 45 to 54 years old, 55 to 64 years old, and 65 years old) according to their age at diagnosis.
    Each hypertensive patient had a matched healthy participant as a control, and the control group The same number is 11,399 people
    .

    Participants' information was entered between 2006 and 2010, and MRI brain scans were performed between 2014 and 2019
    .

    Hypertension in this study is defined as a diagnosis of hypertension (informed by a doctor) or hospitalization records based on the International Classification of Disease Guidelines
    .

    Through MRI scans, the researchers found that in the 35 to 54-year-old age group, compared with participants without hypertension, individuals diagnosed with hypertension were associated with smaller total brain, gray matter, and white matter volumes; compared with controls Compared with the group, participants who were diagnosed with hypertension before the age of 35 had the largest reduction in brain volume; the researchers said that in a single measurement, individuals who were diagnosed with hypertension at a young age had smaller brain volumes.
    The study of measuring brain volume at several time points can confirm whether this is related to more brain volume decrease over time
    .

    To assess dementia, the researchers identified participants with dementia during follow-up
    .

    They compared 124053 hypertensive patients with 124053 matched normal blood pressure controls
    .

    During the 14-year follow-up period, 4626 people developed some form of dementia
    .

    By analyzing the relationship between dementia and blood pressure diagnosis, the researchers found that compared with the control group, individuals diagnosed with high blood pressure between the ages of 35-44 have a significantly higher risk of any type of dementia by 61%; compared with the control group Compared with participants in the same age group, individuals who were diagnosed with high blood pressure between the ages of 45-54 suffered from vascular dementia (a common form of dementia caused by impaired blood flow in parts of the brain, which may occur after one or more small strokes) The risk of vascular dementia is 45% higher in adults aged 35-44 who are diagnosed with hypertension.
    The risk of vascular dementia is 69% higher
    .

    Although the risk of vascular dementia in people diagnosed with hypertension before the age of 35 is 80% higher, there are fewer cases of dementia in the younger participants, and the association with hypertension is not statistically significant, while for those aged 45-54 For individuals with hypertension, the risk association is meaningful
    .

    Unlike vascular dementia, no link was found between the risk of Alzheimer's disease and the age at which hypertension was diagnosed
    .

    The results of this study provide evidence that premature hypertension is related to the occurrence of dementia, and more importantly, this correlation is supported by changes in brain volume structure
    .

    Therefore, the prevention and treatment of high blood pressure to promote health may need to start earlier
    .

    Researchers say that being able to identify patients with early hypertension and providing active screening programs for early intensive hypertension treatment may help reduce the risk of dementia in the future
    .

    Link to the paper: https://doi.
    org/10.
    1161/HYPERTENSIONAHA.
    121.
    17608 Related reading: 9 risk factors for dementia, China accounts for 40%! "The Lancet" released the latest report on prevention of middle-aged dementia? New Oxford research: Hypertension and diabetes can change the brain structure of middle-aged people, weaken the speed of thinking and memory.
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