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▎As a common chronic disease, editors of WuXi AppTec's content team, hypertension affects 245 million people in China
.
In some people’s opinion, as long as there are no symptoms of high blood pressure, there will be no major problems.
Others have some understanding of the dangers of high blood pressure, such as increased cardiovascular diseases such as myocardial infarction, stroke, coronary heart disease, heart failure, and dementia.
Risk
.
But did you know? The harm of high blood pressure goes far beyond that, and it may also increase the risk of certain types of cancer
.
According to a study published in the Journal of the American Heart Association (JAHA), higher blood pressure, including systolic (high pressure) and diastolic (low pressure), is associated with an increased risk of colorectal cancer, especially in men
.
Image source: 123RF Researchers from the University of Tokyo and other institutions analyzed data from the Japanese JMDC database.
A total of 22,201,12 participants with an average age of 44 years old were included, and 58.
4% were men
.
When joining the study, none of the participants took antihypertensive drugs
.
Researchers collected basic health information such as age, gender, height, weight, waist circumference, etc.
; life>
.
According to blood pressure levels, the researchers divided all participants into 4 groups: normal blood pressure: systolic blood pressure <120 mmHg and diastolic blood pressure <80 mmHg; high normal blood pressure: systolic blood pressure of 120 mmHg-129 mmHg and diastolic blood pressure <80 mmHg; Grade 1 hypertension: systolic blood pressure is 130 mmHg-139 mmHg or diastolic blood pressure is 80 mmHg-89 mmHg; grade 2 hypertension: systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg
.
Statistics found that among all participants, 52.
5% had normal blood pressure, 15.
4% had high normal blood pressure, 21% had grade 1 hypertension, and 11.
1% had grade 2 hypertension
.
Compared with participants with normal blood pressure, participants with high normal blood pressure, grade 1 and grade 2 hypertension tended to be older people, men, current smokers and habitual drinkers, and their body mass index (BMI) , Waist circumference, blood sugar, glycosylated hemoglobin and low-density lipoprotein cholesterol and triglyceride levels are higher, and high-density lipoprotein cholesterol levels are lower
.
Image source: 123RF has a total of 6899 new cases of colorectal cancer during the average follow-up period of 3 years
.
After adjusting for the influence of other factors, the researchers found that grade 1 and grade 2 hypertension were associated with an increased risk of colorectal cancer in participants; high normal blood pressure was not significantly associated
.
Compared with participants with normal blood pressure, Grade 1 and Grade 2 hypertension were associated with a 7% and 17% increase in the risk of colorectal cancer, respectively
.
Every 10 mmHg increase in systolic or diastolic blood pressure is associated with a 4% and 6% increase in the risk of colorectal cancer, respectively
.
The researchers found similar associations even in participants who did not have obesity, high waist circumference, diabetes, or dyslipidemia
.
In addition, the researchers also found that the association between grade 1 and grade 2 hypertension and the risk of colorectal cancer is more pronounced in men
.
Among male participants, Grade 1 and Grade 2 hypertension were associated with a 10% and 24% increase in the risk of colorectal cancer, respectively, compared to participants with normal blood pressure
.
Among female participants, the related risks were increased by 3% and 4%, respectively
.
Every 10 mmHg increase in systolic and diastolic blood pressure was associated with a 6% and 7% increase in the risk of colorectal cancer in male participants, while it was 1% and 4% in females, with little association
.
Image source: 123RF As the study is an observational study, it only shows the association between high blood pressure and the risk of colorectal cancer, and does not indicate a causal relationship
.
And the study also has some limitations, such as the average age of the participants is relatively young, part of the data relies on the memories of the participants, and the impact of taking antihypertensive drugs on the risk of colorectal is not analyzed, which may also have an impact on the results of the study
.
The reasons for the association between high blood pressure and increased risk of colorectal cancer are currently unclear
.
Researchers believe that more research is needed to clarify the relevant biological mechanisms and explore the impact of the history of hypertension and treatment on the risk of colorectal cancer
.
The study finally emphasized that colorectal cancer is the world's third most common cancer and the second most common cause of death from cancer.
In 2020, there will be 1.
93 million new cases and more than 930,000 deaths
.
The results of the study showed that untreated high blood pressure is associated with an increased risk of colorectal cancer
.
For hypertensive patients, not only should pay attention to daily blood pressure control, but also the prevention of colorectal cancer; if there are other risk factors for colorectal cancer, or after the screening age, they should be screened in time to reduce colorectal cancer.
Risks, promote the improvement of overall health
.
Recommended reading~ Your body is talking, this article explains insulin resistance! 1 good habit that is good for brain health, do it at least twice a day! Oh my god! The products you eat and use every day may be "toxic"? Nearly one-third of Chinese people have the disease, which may double the risk of breast cancer! How to prevent the coexistence of many diseases! Cancer survivors should be vigilant, more than 40% suffer from multiple chronic diseases.
Reference materials[1] Hidehiro Kaneko, et al.
,(2021).
Untreated Hypertension and Subsequent Incidence of Colorectal Cancer: Analysis of a Nationwide Epidemiological Database.
Journal of the American Heart Association, DOI: 10.
1161/JAHA.
121.
022479.
[2] Latest global cancer data: Cancer burden rises to 19.
3 million new cases and 10.
0 million cancer deaths in 2020.
Retrieved Nov 15 ,2021,from https:// /fr/news-events/latest-global-cancer-data-cancer-burden-rises-to-19-3-million-new-cases-and-10-0-million-cancer-deaths-in-2020/ Statement: WuXi AppTec's content team focuses on introducing global biomedical health research progress
.
This article is for the purpose of information exchange only.
The opinions expressed in the article do not represent the position of WuXi AppTec, nor does it mean that WuXi AppTec supports or opposes the views in the article
.
This article is not a treatment recommendation either
.
If you need guidance on treatment plans, please go to a regular hospital for treatment
.
.
In some people’s opinion, as long as there are no symptoms of high blood pressure, there will be no major problems.
Others have some understanding of the dangers of high blood pressure, such as increased cardiovascular diseases such as myocardial infarction, stroke, coronary heart disease, heart failure, and dementia.
Risk
.
But did you know? The harm of high blood pressure goes far beyond that, and it may also increase the risk of certain types of cancer
.
According to a study published in the Journal of the American Heart Association (JAHA), higher blood pressure, including systolic (high pressure) and diastolic (low pressure), is associated with an increased risk of colorectal cancer, especially in men
.
Image source: 123RF Researchers from the University of Tokyo and other institutions analyzed data from the Japanese JMDC database.
A total of 22,201,12 participants with an average age of 44 years old were included, and 58.
4% were men
.
When joining the study, none of the participants took antihypertensive drugs
.
Researchers collected basic health information such as age, gender, height, weight, waist circumference, etc.
; life>
.
According to blood pressure levels, the researchers divided all participants into 4 groups: normal blood pressure: systolic blood pressure <120 mmHg and diastolic blood pressure <80 mmHg; high normal blood pressure: systolic blood pressure of 120 mmHg-129 mmHg and diastolic blood pressure <80 mmHg; Grade 1 hypertension: systolic blood pressure is 130 mmHg-139 mmHg or diastolic blood pressure is 80 mmHg-89 mmHg; grade 2 hypertension: systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg
.
Statistics found that among all participants, 52.
5% had normal blood pressure, 15.
4% had high normal blood pressure, 21% had grade 1 hypertension, and 11.
1% had grade 2 hypertension
.
Compared with participants with normal blood pressure, participants with high normal blood pressure, grade 1 and grade 2 hypertension tended to be older people, men, current smokers and habitual drinkers, and their body mass index (BMI) , Waist circumference, blood sugar, glycosylated hemoglobin and low-density lipoprotein cholesterol and triglyceride levels are higher, and high-density lipoprotein cholesterol levels are lower
.
Image source: 123RF has a total of 6899 new cases of colorectal cancer during the average follow-up period of 3 years
.
After adjusting for the influence of other factors, the researchers found that grade 1 and grade 2 hypertension were associated with an increased risk of colorectal cancer in participants; high normal blood pressure was not significantly associated
.
Compared with participants with normal blood pressure, Grade 1 and Grade 2 hypertension were associated with a 7% and 17% increase in the risk of colorectal cancer, respectively
.
Every 10 mmHg increase in systolic or diastolic blood pressure is associated with a 4% and 6% increase in the risk of colorectal cancer, respectively
.
The researchers found similar associations even in participants who did not have obesity, high waist circumference, diabetes, or dyslipidemia
.
In addition, the researchers also found that the association between grade 1 and grade 2 hypertension and the risk of colorectal cancer is more pronounced in men
.
Among male participants, Grade 1 and Grade 2 hypertension were associated with a 10% and 24% increase in the risk of colorectal cancer, respectively, compared to participants with normal blood pressure
.
Among female participants, the related risks were increased by 3% and 4%, respectively
.
Every 10 mmHg increase in systolic and diastolic blood pressure was associated with a 6% and 7% increase in the risk of colorectal cancer in male participants, while it was 1% and 4% in females, with little association
.
Image source: 123RF As the study is an observational study, it only shows the association between high blood pressure and the risk of colorectal cancer, and does not indicate a causal relationship
.
And the study also has some limitations, such as the average age of the participants is relatively young, part of the data relies on the memories of the participants, and the impact of taking antihypertensive drugs on the risk of colorectal is not analyzed, which may also have an impact on the results of the study
.
The reasons for the association between high blood pressure and increased risk of colorectal cancer are currently unclear
.
Researchers believe that more research is needed to clarify the relevant biological mechanisms and explore the impact of the history of hypertension and treatment on the risk of colorectal cancer
.
The study finally emphasized that colorectal cancer is the world's third most common cancer and the second most common cause of death from cancer.
In 2020, there will be 1.
93 million new cases and more than 930,000 deaths
.
The results of the study showed that untreated high blood pressure is associated with an increased risk of colorectal cancer
.
For hypertensive patients, not only should pay attention to daily blood pressure control, but also the prevention of colorectal cancer; if there are other risk factors for colorectal cancer, or after the screening age, they should be screened in time to reduce colorectal cancer.
Risks, promote the improvement of overall health
.
Recommended reading~ Your body is talking, this article explains insulin resistance! 1 good habit that is good for brain health, do it at least twice a day! Oh my god! The products you eat and use every day may be "toxic"? Nearly one-third of Chinese people have the disease, which may double the risk of breast cancer! How to prevent the coexistence of many diseases! Cancer survivors should be vigilant, more than 40% suffer from multiple chronic diseases.
Reference materials[1] Hidehiro Kaneko, et al.
,(2021).
Untreated Hypertension and Subsequent Incidence of Colorectal Cancer: Analysis of a Nationwide Epidemiological Database.
Journal of the American Heart Association, DOI: 10.
1161/JAHA.
121.
022479.
[2] Latest global cancer data: Cancer burden rises to 19.
3 million new cases and 10.
0 million cancer deaths in 2020.
Retrieved Nov 15 ,2021,from https:// /fr/news-events/latest-global-cancer-data-cancer-burden-rises-to-19-3-million-new-cases-and-10-0-million-cancer-deaths-in-2020/ Statement: WuXi AppTec's content team focuses on introducing global biomedical health research progress
.
This article is for the purpose of information exchange only.
The opinions expressed in the article do not represent the position of WuXi AppTec, nor does it mean that WuXi AppTec supports or opposes the views in the article
.
This article is not a treatment recommendation either
.
If you need guidance on treatment plans, please go to a regular hospital for treatment
.
