Xinhua News Agency, Sydney, August 24 (Reporter Hao Yalin) A new study by an Australian research team found that tissue-resident memory T cells (TRM cells) have different molecular characteristics and behaviors in different tissue environments of the human body.
TRM cells are a kind of immune cells that only exist in human tissues.
A research team led by Australia's "Peter Dougherty Institute of Infection and Immunity" compared barrier organs (such as skin) exposed to the environment with solid organs such as the liver and found that the tissue environment where TRM cells reside has a significant impact The way these cells exert their immune function
Studies have found that there is a protein called transforming growth factor-β in the skin that can inhibit the activation of TRM cells in unnecessary circumstances, so as to prevent the human immune system from attacking itself
The researchers said that the discovery that TRM cells have unique molecular characteristics and behaviors in specific tissues will help develop effective vaccines and immunotherapies based on T cells.
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