echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > Research finds the enzyme that determines COVID-19 mortality or Long-COVID

    Research finds the enzyme that determines COVID-19 mortality or Long-COVID

    • Last Update: 2021-09-03
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Researchers from the University of Arizona, in collaboration with Stony Brook University and Wake Forest University School of Medicine, analyzed blood samples from two cohorts of COVID-19 patients and found that the circulation of this enzyme (secreted phospholipase A2 group IIA, or sPLA2- IIA) may be the most important factor predicting which severe COVID-19 patients will eventually die from the virus


    The low concentration of sPLA2-IIA found in healthy people is similar to an active enzyme in rattlesnake venom.


    Floyd (Ski) Chilton said that when active enzymes circulate at high levels, it has the ability to "shred" the membranes of vital organs


    Chilton said: "This is a bell-shaped curve of disease resistance and host tolerance


    Maurizio Del Poeta (Maurizio Del Poeta), a co-author of the study and a distinguished professor in the Department of Microbiology and Immunology at Stony Brook University School of Together, "This research has developed a new treatment program to reduce or even prevent COVID-19 mortality





    Del Poeta said: "The idea of ​​identifying potential prognostic factors in COVID-19 patients originated from Dr.


    Del Poeta and his team collected stored plasma samples, began to analyze medical charts, and tracked key clinical data of 127 patients hospitalized at Stony Brook University from January to July 2020


    Chilton said: "It is true that this is a small cohort, but in this case, it is a heroic effort to obtain them and all relevant clinical parameters from each patient


    The research team was able to analyze thousands of patient data points using machine learning algorithms




    "In this study, we were able to identify the patterns of metabolites present in the human body who died of this disease," said Justin Snider, the lead author of the study and an assistant research professor in the Department of Nutrition at the University of Arizona.


    Using the same machine learning method, the researchers developed a decision tree to predict the mortality rate of COVID-19


    Chilton has been studying this enzyme for more than 30 years.



    The role of the sPLA2-IIA enzyme has been studied for half a century, and it "may be the most studied member of the phospholipase family," Chilton explained
    .

    The lead researcher of the Wake Forest University study, Charles McCall (Charles McCall), called this enzyme a "pulverizer" because it is known to be effective in severe cases such as bacterial sepsis, hemorrhagic and cardiac shock.
    It is common in inflammatory events
    .

    Previous studies have revealed how this enzyme destroys microbial cell membranes in bacterial infections, and its genetic ancestor similar to a key enzyme found in snake venom
    .

    Chilton said that this protein "has a high degree of sequence homology with the active enzymes in rattlesnake venom, just like the venom flowing through the body.
    It has the ability to bind to receptors at neuromuscular junctions and may make these muscles Loss of function
    .
    "

    "About one-third of people have been infected with the new coronavirus for a long time.
    Many of them were active before, but now they can’t walk 100 yards
    .
    The question we are studying is: If this enzyme is still relatively high and active, Is it related to the long-term COVID symptoms we are seeing?"

    Journal Reference :

    1. Justin M.
      Snider, Jeehyun Karen You, Xia Wang, Ashley J.
      Snider, Brian Hallmark, Manja M.
      Zec, Michael C.
      Seeds, Susan Sergeant, Laurel Johnstone, Qiuming Wang, Ryan Sprissler, Tara F.
      Carr, Karen Lutrick, Sairam Parthasarathy, Christian Bime, Hao H.
      Zhang, Chiara Luberto, Richard R.
      Kew, Yusuf A.
      Hannun, Stefano Guerra, Charles E.
      McCall, Guang Yao, Maurizio Del Poeta, Floyd H.
      Chilton.
      Group IIA secreted phospholipase A2 is associated with the pathobiology leading to COVID-19 mortality .
      Journal of Clinical Investigation , 2021; DOI: 10.
      1172/JCI149236



    University of Arizona.
    "Like venom coursing through the body: Researchers identify mechanism driving COVID-19 mortality.
    " ScienceDaily.
    ScienceDaily, 24 August 2021.
    <

    University of Arizona.
    (2021, August 24).
    Like venom coursing through the body: Researchers identify mechanism driving COVID-19 mortality.
    ScienceDaily .
    Retrieved August 24, 2021 from

    University of Arizona.
    "Like venom coursing through the body: Researchers identify mechanism driving COVID-19 mortality.
    " ScienceDaily.
    (accessed August 24, 2021).


    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.