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    Home > Research group of Professor Song Jibin and Professor Yang huanghao of Fuzhou University: inorganic tellurium nanowire prodrug for enhancing the generation of reactive oxygen species and glutathione depletion for specific tumor treatment

    Research group of Professor Song Jibin and Professor Yang huanghao of Fuzhou University: inorganic tellurium nanowire prodrug for enhancing the generation of reactive oxygen species and glutathione depletion for specific tumor treatment

    • Last Update: 2019-06-27
    • Source: Internet
    • Author: User
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    Compared with normal tissues and organs, the concentrations of hydrogen peroxide (H 2O 2) and glutathione (GSH) in tumor microenvironment were much higher than those in normal tissues Although many nanosystems with H 2O 2 response or H 2O 2 activation have been used in tumor diagnosis, imaging and treatment, these systems mainly enhance the cancer treatment effect through the drug release caused by H 2O 2 or the treatment in response to external stimulation At the same time, nanoprodrugs that specifically produce toxic products in tumors have not been reported Therefore, it is of great significance to develop nano prodrugs stimulated by H 2O 2 that can directly kill tumor cells after reacting with H 2O 2 Recently, the research group of Professor Song Jibin and Professor Yang huanghao of Fuzhou University has made a new breakthrough in the field of inorganic nanoprodrug (chem SCI 2019, DOI: 10.1039/c 9sc01070j) Prof song Jibin is a doctoral supervisor of the school of chemistry, Fuzhou University and a distinguished professor of Minjiang scholars He graduated from Nanyang University of technology in Singapore, majoring in biomedical engineering, and then engaged in post doctoral research in the molecular imaging center of the National Institutes of Health (NIH), with the research direction of molecular imaging and cancer diagnosis and treatment Song Jibin's research group has been engaged in the preparation of luminescent organic and inorganic materials, the synthesis of responsive polymers and the self-assembly of responsive nanoparticles, and the research on molecular imaging, biological analysis, medical detection, new drug carriers, etc., involving the interdisciplinary research fields of chemistry, materials, biology, medicine, etc In terms of paper publication, more than 60 SCI papers have been published, among which more than 30 papers have been published as the first author / corresponding author (24 papers have impact factors greater than 10) It mainly includes: Nat Protoc., NAT Commun., acc chem Res., J am Chem SOC., angelw Chem Int ed., adv mater., acsnano, chem SOC Rev., etc Prof Yang huanghao, Professor of Fuzhou University In 2011, he was awarded the National Science Fund for Distinguished Young Scholars, in 2013, he was selected as a distinguished professor of Yangtze River scholars by the Ministry of education, in 2014, he was selected as a member of the national ten thousand talents plan, in 2014, he was selected as a member of the Royal Society of chemistry, in 2015, he was selected as a national advanced worker, and in 2015, he was selected as a member of the National Youth Federation He once served as the vice president of the school of chemistry of Fuzhou University and the dean of the school of biological science and engineering of Fuzhou University, and now he is the vice president of Fuzhou University, the director of the Key Laboratory of the Ministry of education, and the director of the engineering research center of Fujian Province In the field of scientific research, we have carried out more in-depth research in analytical chemistry, nanomedicine, biomedical engineering and other fields, and achieved systematic and innovative research results in methodology and practical application He has presided over 1 project of national 973 Plan, 2 projects of national 863 plan, 1 special project of national major scientific instrument and equipment development, and 2 key projects of National Natural Science Foundation More than 110 academic papers have been published in the past five years, including more than 20 papers published in nature, J am Chem SOC., angel Chem Int ed., advanced materials and other journals with influence factors greater than 10 Leading edge scientific research achievements: hormesis effect of inorganic tellurium nanowire prodrug, which can enhance the generation of reactive oxygen species and glutathione depletion for specific cancer treatment, tells us that "dose determines poison" In recent years, many materials that are traditionally considered toxic are used to treat diseases, such as arsenic trioxide delivery system with pH response for cancer treatment (ACS Nano 2015, 9, 2749-2759), sulfur dioxide gas treatment of cancer (ACS Nano 2019, 13, 2103-2113) Among them, the toxicity of tellurium is far less than that of tellurium compounds, even lower than some materials that have been widely used in biomedicine, such as selenium, etc., but its application in biomedicine remains to be developed Tellurium reacts with hydrogen peroxide to form telluric acid ions (teo66 -) which are highly toxic, and the concentration of H 2O 2 in tumor microenvironment is much higher than that in normal tissue Based on this, the author has constructed an inorganic nanoprodrug, tellurium nanowires (tenws), which can be used for highly selective treatment of tumor induced by H 2O 2, and can also destroy the redox balance of tumor site by consuming GSH twice (Fig 1, chem SCI 2019, DOI: 10.1039/c9sc01070j) Fig 1 Schematic diagram of H 2O 2 / GSH corresponding inorganic nano prodrug tenws for highly selective tumor treatment (source: Chemical Science) Fig 2 Related characterization of tenws and H 2O 2 and GSH reaction (source: Chemical Science) The author first verified the reaction process of tenws in tumor microenvironment (Fig 2), and found that tenws After the reaction with H 2O 2, the consumption of solution was gradually reduced The hexavalent tellurium product from this reaction will continue to consume GSH to form tetravalent tellurium, and the acidity of tumor microenvironment has no obvious effect on this process Fig 3 Selective killing of tenws in cells and therapeutic effect in vivo (source: Chemical Science) Then, the author verified the specific killing effect of Tellurium on tumors The results showed that the material had high selectivity to cancer cells, and found that MCF-7 cells were the most sensitive to tenws The authors also discussed the mechanism of cell death caused by tenws, and found that tenws can cause cell death through caspase independent apoptosis and autophagic death, and it can cause immune response to kill tumor with high selectivity, and the death mechanism is applicable to living body (Fig 3) In conclusion, the author has successfully developed an intelligent inorganic nanoprodrug that can react with H 2O 2, and further interact with GSH through metal reduction reaction, so as to increase the level of ROS in cells and kill cells efficiently In addition, the product of the reaction between tenws and H 2O 2 will lead to cell death through a variety of complex ways It has high tumor accumulation efficiency and high targeted tumor treatment effect It is an inorganic nano prodrug with great application prospect This work was published on Chemical Science (DOI: 10.1039 / c9sc01070j) under the title of "an inorganic prodrug, tellurium nanowires with enhanced rosgeneration and GSH completion for selective cancer therapy" The first author is Dr Wu Ying of Fuzhou University, and the corresponding author is Professor Song Jibin and Professor Yang huanghao of Fuzhou University, Tao Guo, Yuan Qiu, Yan Lin, Yunyan Yao, Weibin Lian, Lisen Lin, Jibin Song andHuanghao Yang )。
    Nowadays, people and scientific research have been paid more and more attention in the economic life China has ushered in the "node of science and technology explosion" Behind the progress of science and technology is the work of countless scientists In the field of chemistry, in the context of the pursuit of innovation driven, international cooperation has been strengthened, the influence of Returned Scholars in the field of R & D has become increasingly prominent, and many excellent research groups have emerged in China For this reason, CBG information adopts the 1 + X reporting mechanism CBG information, chembeangoapp, chembeango official microblog, CBG wechat subscription number and other platforms jointly launch the column of "people and scientific research", approach the domestic representative research group, pay attention to their research, listen to their stories, record their demeanor, and explore their scientific research spirit.
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