Research group of Professor Song Zhenlei of Sichuan University: development and application of new joint silicon reagent

Functional chemical molecular entities, such as lead new reagents, are important innovative sources and driving forces for the development of organic chemistry Recently, the research team of Professor Song Zhenlei of Sichuan University has made important progress in the development and application of new silicone reagents (angel.chem Int ed 2018, DOI: 10.1002/anie.201800513) The research team of Professor Song Zhenlei has been committed to the development, reaction and application of new silicone reagents and synthons for a long time In recent years, a kind of "Gemini chemistry" with remarkable characteristics has been developed, and the research work has made the following three progress: 1) a general and efficient synthesis method of this kind of structure has been developed, which has solved the challenge of constructing Gemini structure, which is extremely crowded in space, and has broken the source barrier of single structure and expensive price of commercial reagents There are nearly 20 kinds of reagents and synthetic libraries including chiral bissilyl allylic reagents, bissilyl alcohol derivatives, dialdehyde, dialdehyde and high allyl alcohol 2) The stereoscopic effect, electronic effect, silicon migration, bifunctional group and other special properties and functions of Gemini silicon have been systematically explored, and 15 novel gemini reaction methodologies have been developed It not only shows high accuracy in the introduction of functional groups and stereochemistry control, but also realizes effective inversion of some conventional chemistry, region and stereoselectivity 3) With the key step of the reaction methodology of Gemini silicon, bryostatin 8, (-) - exiguolide, nematocida oxylide and other complex natural products with important biological activities have been synthesized efficiently, which highlights the important application value of Gemini silicon chemistry Brief introduction to Professor Song Zhenlei, professor and doctoral supervisor of Department of pharmaceutical chemistry, West China College of pharmacy, Sichuan University In 1996, he was admitted to the base class of Chemistry Department of Lanzhou University From 2000 to 2005, he studied organic chemistry with Professor Tu Yongqiang, academician of Chinese Academy of Sciences From 2005 to 2008, he went to the Department of chemistry of the University of Minnesota and the school of pharmacy of the University of Wisconsin Madison to engage in postdoctoral research under the guidance of Professor Richard P hsung He returned to China in March 2008 and has been employed in West China Pharmaceutical College of Sichuan University In 2017, he was supported by excellent youth fund of National Natural Science Foundation of China So far, more than 50 SCI papers have been published in Chem Rev., J am Chem SOC., angelw Chem Int ed., NAT Prod Rep, chem Commin., org Lett And other international high-level academic journals The research achievements have been positively recommended by international famous academic media for 15 times, and have been invited to write manuscripts, reviews and characteristic columns such as organic reactions for 8 times It has won 8 awards and honors including 2013 youth Chemistry Award of China Chemical Society and 2018 Sichuan Youth Science and technology award Cutting edge scientific research achievements: the development and application of new silicon reagents (me3si − sime2 [o-con (i-pr) 2c6h4]) silicon reagents have very extensive and important application value in industry and academia For example, it can be used to synthesize allylidene silicon, allylidene silicon, aryl silicon and acyl silicon, or to protect the hydroxyl group by forming a silicon ether The reagents are mainly divided into symmetrical reagents and asymmetric reagents Because of the two identical silicon groups, it is very difficult to distinguish the reaction products in the subsequent conversion This point can be solved by the application of asymmetric silica reagent However, most of the traditional asymmetric silica reagents contain Si halogen bonds which are very sensitive to air and water vapor It is not only toxic, but also inconvenient to store and use In particular, these reagents can only give moderate regioselectivity and stereoselectivity in many reactions, such as alkyne disilicization In view of the above problems, the research group has designed and developed a new type of unsymmetrical silica reagent me 3Si − sime2 [o-con (i-pr) 2c6h 4], which is substituted by amide, by the guidance of amide group The preparation method of the reagent is simple, it is a white solid, it is stable for air and water vapor, and it is very convenient for storage and operation By using this reagent, the group has successfully realized the high stereoscopic and regioselective reaction of alkyne disilicization, and synthesized a series of novel alkenyl disilicated compounds and a new silicon substituted flavonoids The research work was recently published in angew Chem Int ed (DOI: 10.1002 / anie 201800513), and was recommended as inside cover (source: angelw Chem Int ed.) this work has been supported by the excellent youth fund program (21622202) and major program (21290180) of the National Natural Science Foundation of China, mainly completed by Dr Xiao Peihong, master Cao Yanjun, master GUI Yingying, etc Nowadays, people and scientific research have been paid more and more attention in the economic life China has ushered in the "node of science and technology explosion" Behind the progress of science and technology is the work of countless scientists In the field of chemistry, in the context of the pursuit of innovation driven, international cooperation has been strengthened, the influence of Returned Scholars in the field of R & D has become increasingly prominent, and many excellent research groups have emerged in China For this reason, CBG information adopts the 1 + X reporting mechanism CBG information, chembeango app, chembeango official microblog, CBG wechat subscription number and other platforms jointly launch the column of "people and scientific research", approach the domestic representative research group, pay attention to their research, listen to their stories, record their demeanor, and explore their scientific research spirit.