Research group of Professor Yang Yingwei of Jilin University: water soluble biphenyl extended column [6] arene for selective precipitation of organic sulfonates

The molecular design, molecular recognition and molecular assembly of the lead functional macrocyclic receptor have become a hot research field in supramolecular chemistry The exploration and construction of new functional macrocyclic receptor compounds has been the power and innovation source of enriching the content of supramolecular science and promoting the development of supramolecular science Recently, Professor Yang Yingwei's team of Jilin University has carried out a series of innovative work in the design and synthesis of new supramolecular macrocyclic receptors Brief introduction of Yang Yingwei's research group the project composition was established in March 2011 It aims to design and synthesize new organic supramolecular macrocyclic compounds and construct self-assembly functional system, intelligent organic-inorganic-high molecular hybrid composite and functional porous materials with the function orientation of biomedicine, environmental sustainable development and energy storage It can be used in drug targeted delivery and controlled release, selective adsorption and separation of gas / hazardous substances, pesticide sensing and detection, battery materials and other specific applications Since its establishment, the research group has published nearly 100 papers in international core journals, such as acc chem Res., chem SOC Rev., adv mater., J am Chem SOC., chem SCI., chem Commun., small, macrolecules, etc Recently, Professor Yang Yingwei, the leader of scientific research, was selected as "2017 highly cited scientist, clarivate Analytics" and "2017 Chinese most cited researcher" by Elsevier, Elsevier), which means that the research group has an important international influence in its research field, and the scientific research achievements made a great contribution to the development of the field Prof Yang Yingwei, Professor, Ph.D supervisor, School of chemistry, Jilin University, nanoarchitecture international cooperation laboratory In 2000, he graduated from the Department of chemistry of Nankai University and obtained his bachelor's degree In the same year, he was sent to Nankai University for direct doctoral research under the guidance of Professor Liu Yu and obtained his doctor of Science degree from Nankai University in 2005 From 2005 to 2010, he successively worked in Arizona State University, University of California, Los Angeles and University of America California and Irvine are engaged in postdoctoral research Their co mentors are Professor John C Chaput (currently working at the University of California, Irvine), academician Sir Fraser Stoddart (2016 Nobel Prize winner in chemistry, now working at Northwestern University) and Professor Zhibin Guan Since 2011, he has worked in the school of chemistry, Jilin University Professor Yang Yingwei's main research fields are organic-inorganic hybrid materials, intelligent polymer composite materials and organic supramolecular chemistry The research contents include: the construction of nanovalve drug controlled release system and its application in the field of targeted delivery of anticancer drugs, molecular machines, organic-inorganic hybrid materials and their sensing, detection and removal of harmful substances, the design and preparation of novel sof / MOF / COF porous materials and membranes, gas selective storage and separation, drug / protein / gene transfer based on polymer composite materials System and antibacterial system, design and synthesis of new supramolecular macrocyclic aromatics, molecular recognition and assembly, etc He has presided over three general programs of NSFC and more than ten other funds of the Ministry of education; he has published more than 120 SCI papers in acc chem Res., chem SOC Rev., JACS, adv mater., angel Chem., chem SCI., chem Commun., and other important journals; he has been invited to write four chapters of monograph Scientific research achievements have been reported by nature, nature chemistry, nature materials, ACS newsworthy chemistry, chemistry world, chemistry views, materialsviews, Science Daily and other periodical media for more than 100 times More than 30 invited reports were made at important academic conferences at home and abroad The research work has been selected as the cover and inner cover of the magazine for many times; he has been invited to write and publish several personal research reviews and reviews for acc chem Res., chem SOC Rev., adv mater., chem Rec., chem Commun., J mater Chem B and other journals The scientific research achievement "preparation and application of functional organic supramolecular nano hybrid materials" won the second prize of Jilin Province Natural Science Academic Achievement Award (the first adult); was selected into "2013 China's 100 most influential international academic papers"; was selected into "2012 leader 5000 top academic papers of China's fine science and Technology Journals"; was appraised as J mater Chem B, SCI China chem., chin Chem Lett And many other outstanding papers, high impact papers and high citation papers in magazines; selected in 2017 "global high cited scientist" of corewellian, 2017 "Chinese high cited scholar" of Elsevier, and chemcomm emerging of Royal Chemical Society Investigator, the Sixth Batch of top innovative talents in Jilin Province, Jilin University's Peiying project, Jilin University's national outstanding youth fund reserve candidate cultivation plan and Jilin University's School of chemistry young teachers' innovation ability improvement plan, etc He was invited to serve as the foundation evaluation expert of the European Commission, the fund reviewer of Israel science foundation, Belgium Flanders research foundation, Chile National Science and Technology Commission, British Lung Foundation, National Natural Science Foundation, China Postdoctoral fund, etc.; as the editorial board member of scientific reports magazine under Nature Publishing Group, and Chinese chemical letters Young Editorial Committee of journal, Editorial Committee of Journal of nanomedicineresearch, Editorial Committee of Journal of Chongqing University of science and technology, guest editor of Chinese Journal of chemistry, etc.; specially invited reviewers of more than 90 kinds of magazines, such as science advanced, nature communications, acc chem Res., chem SOC Rev., advanced Mater., JACS, angel Chem., ACS Nano, etc Mr Wu Jiarui, a postgraduate, received his Bachelor of Science degree from the school of chemistry, Lanzhou University in 2014 Now he is a postgraduate of 2016 in the research group of Professor Yang Yingwei, the Joint Laboratory for international cooperation of nanoarchitecture chemistry, Jilin University The main research fields are the design and synthesis of new supramolecular macrocycles, molecular recognition and assembly, the design and preparation of new sofporous materials, and gas selective storage and separation Frontier research achievements: Professor Yang Yingwei's team of Jilin University has carried out a series of innovative work in the design and synthesis of new supramolecular macrocyclic receptors In recent years, for the first time, they have designed and obtained a class of supramolecular macrocyclic receptors with novel structure and excellent properties, namely biphenyl extended pillar [n] arenes (Fig 1) From the structural analysis, this kind of macrocyclic molecule has the rigid ring skeleton structure of traditional macrocyclic molecules, such as columnar aromatics, calixarenes, cucurbit ureas, and has the advantages of expanding the size of electron rich cavities and multifunctional modification sites From the point of view of organic synthesis, it has the advantages of mild preparation conditions, high ring-forming yield, easy access to initial raw materials, simple separation and purification From the perspective of molecular recognition, biphenyl extended aromatics (such as [2] bp-exp6) have very good host guest complexation ability for benzene series molecules such as toluene and xylene in the solid state (such as single crystal), suggesting that this macrocyclic molecule has potential application value in petrochemical purification (chem Commun 2016, 52, 5804 – 5807 Doi: 10.1039/c6cc01892k) Fig 1 The design and synthesis route of biphenyl extended column aromatics (source: chem Commin.) based on this part of work, they have successfully designed and prepared a series of biphenyl extended column [6] aromatics derivatives (Fig 2) through a large number of methodological screening and experimental attempts, and the synthesis route is novel, the synthesis method is simple and smooth, and the conditions are mild and controllable Figure 2 Synthesis route of biphenyl extended column [6] arene derivatives (source: EUR J org Chem., DOI: 10.1002/ejoc.201800112) Based on the intrinsic advantages of biphenyl extended column [6] arene, the cationic water-soluble biphenyl extended column [6] arene (cwbpp6) shows strong recognition ability and object selectivity for sulfonates It has a high binding constant of 106m-1 with the host guest containing naphthalene cyclosulfonate What's more surprising is that cwbp6 can preferentially recognize and precipitate 2,6-naphthalene sulfonate in water system (Figure 3), which implies that cwbp6 will be an effective detection and separation reagent for sulfonate compounds It is reported that this is the first report on the effective selective precipitation of Sulfonates by using functional macrocyclic receptors Fig 3 Effective recognition and precipitation of water soluble biphenyl extended column [6] arene 2, 6-naphthalene sulfonate object (source: EUR J org Chem., DOI: 10.1002 / ejoc 201800112) was recently published in the European Journal of organic chemistry The first author of this paper is Wu Jiarui, a 2016 graduate student of the school of chemistry of Jilin University The collaborators include Professor Li Chunju of Shanghai University and three teachers Wang Chunyu, Tao Yanchun and Wang Yan of Jilin University The research was supported by the National Natural Science Foundation of China (51673084) and Jilin Province university joint construction project new materials project (sxgjsf2017-3) Original link: http://onlinelibrary.willey.com/doi/10.1002/ejoc.201800112/full Professor Yang Yingwei research group homepage: https://ywyang.wix.com/jlugroup