Research progress in the pharmacological activities of Eucommia ulmoides Oliv

Last revision: 2012-11-15 06:26 classification: efficacy and action: 0 people commented that Eucommia ulmoides Oliv Is the dry bark of Eucommia ulmoids Oliv It is a valuable nourishing medicine in China It has many effects, such as tonifying the liver and kidney, strengthening the muscles and bones, lowering blood pressure, and calming the fetus Eucommia ulmoides Oliv is a kind of unique medicinal material in China, which has a long history of medicinal use and has a wide range of clinical applications In recent years, the research work of Eucommia ulmoides Oliv has been in-depth at home and abroad Zhang Liping et al Extracted the effective component of reducing blood pressure from Eucommia ulmoides Oliv The content in the skin was about three times stronger than that in the leaves The extract of Eucommia ulmoides Oliv Had a very obvious and lasting effect on reducing blood pressure in cats The intensity of reducing blood pressure increased with the increase of the dose, and the duration of reducing blood pressure also extended 50% of the aqueous extracts of Eucommia leaves, hawthorn and kudzu root were given to rats by gavage The serum TC and TG of the dose group were significantly reduced (P < 0.05), and the serum HDL-C was increased to a certain extent, which proved that the compound Eucommia leaves extract had a certain effect on regulating blood lipid In the study of human body experiment, 30 patients with hypertension took the compound Eucommia mixture for 4 weeks, the blood pressure decreased by 15.33 ± 14.85 / 10.90 ± 10.66mmhg on average, among which 9 cases were effective, 14 cases were effective, and the effective rate was 76.67% The difference between the two groups was significant (P < 0.05) Compound eucommia leaf mixture can obviously improve the symptoms of dizziness, palpitation, fidgety and tenderness of knee and waist in patients with hypertension, and can obviously reduce the serum and C in the taking group and regulate the blood lipid The intraperitoneal perfusion of Eucommia ulmoides extract can significantly expand the caliber of the mouse auricle capillary, increase the number of capillary network opening, accelerate the blood flow, improve the microcirculation function of the body, thus affecting the body constitution and disease resistance The coniferoside (s n squat n) in Eucommia ulmoides leaves is an inhibitor of angiotensin and camp, and can increase coronary blood flow In addition, the content of water-soluble silicon and calcium is very high, which can participate in the regulation of cardiovascular function By injecting 20% and 50% ethanol extracts of Eucommia leaves into mice, the transformation function of spleen lymphocytes and phagocytosis function of macrophages in mice were significantly enhanced, but there was no significant effect on spleen antibody forming cells in normal mice The results showed that the ethanol extracts of Eucommia leaves and cortex had the same immunopharmacological effect The ethanol extracts of Eucommia leaves could enhance the cellular immune function and non-specific immune function, but had no significant effect on humoral immune function It was speculated that the ethanol extracts of Eucommia leaves might have some therapeutic effect on diseases caused by the decrease of cellular immune function The extract of eucommia tea soaked in hot water was frozen with 1% NaOH, and the alkaline substance obtained after drying was acid polysaccharide containing glucuronic acid The alkaline substance had the function of anti destroying human immune system virus and might be used to prevent and treat AIDS The results showed that Eucommia ulmoides extract had a certain effect on the normal contraction of uterine smooth muscle, but had a significant antagonistic effect on the strong contraction of uterine smooth muscle caused by the posterior pituitary, and increased with the increase of dose Compared with the posterior pituitary alone, the contraction frequency and activity decreased significantly Like progesterone, duzhongye granule has obvious antagonism to mice abortion caused by posterior pituitary, which can reduce the number of abortion animals and increase the number of offspring The mixture of Eucommia ulmoides Oliv and asarum can improve the activity of scavenging free radicals of cat and NOS, block the chain reaction of free radicals, increase the content of no, make its biological effect play a lasting role in anti-aging.9.mice were given the aqueous extract of Eucommia ulmoides Oliv It was found that the water extract of Eucommia ulmoides Oliv Leaves could significantly reduce the activity of SOD and GSH PX in erythrocytes and lung tissues of aging model mice, inhibit the decrease of SOD and GSP PX caused by D-galactose, and inhibit the lipid peroxidation in lung tissues and erythrocytes induced by D-galactose The increase of MDA has a significant inhibitory effect Five a-glucosidase inhibitory components were isolated from eucommia tea n after methanol extraction, which can block or delay the production of glucose and intestinal absorption, so as to maintain the appropriate blood glucose value in vivo In addition, a-glucosidase plays an important role in the post transcription process of sugar chain transfer and expression on the cell surface, which is crucial for cell recognition The methanol extract of Eucommia ulmoides could inhibit the a-glucosidase by 92%, and also the sucrase in rat intestine It can be seen that Eucommia ulmoides Oliv may be an ideal food therapy product for diabetic and obese patients The water extract of Eucommia ulmoides Oliv And the different extracts of the water extract and UMR106 osteoblast like cells were cultured together in vitro The results showed that the water extract had the strongest effect on promoting cell proliferation at 0.4mg · ml for 48 hours, and the ethyl acetate extract and n-butanol extract had a certain effect on cell proliferation, but the ethyl acetate and n-butanol extract had a certain effect on promoting cell proliferation The results showed that the polar part of Eucommia ulmoides may contain the active component h which acts directly on osteoblasts Many lignans in Eucommia ulmoides leaves have high antitumor activity H Syringin diglucoside has a good activity in the P388 (PS) system of lymphocytic leukemia, the concentration of which is 12.5mg · kg ~, which can control t / C value ≥ 126; the effective components of Eucommia ulmoides leaves, geniposide and geniposide, also have antitumor activity Duzhongkang granule can significantly prolong the time of climbing rope and the time of exhaustion of load-bearing swimming in mice, and has the effect of strengthening physical strength Although it has no obvious effect on the hypoxia tolerance of mice under normal pressure, it can improve the survival rate of mice under the cold temperature of - 8 ℃, and it also has the trend of improving the survival rate of mice compared with the hot stimulation at 45 ℃, which has the obvious effect of anti stress and enhancing the tolerance to external stimulation 。 Chlorogenic acid in Eucommia ulmoides leaves has a strong antibacterial effect; aucubin in peach leaves has a significant liver protection effect, it will produce an obvious antiviral effect after pre culture together with glucosidase, and inhibit the replication of hepatitis B virus DNA It was found that the combination of Eucommia ulmoides Oliv and ginseng could enhance the tissue repair and immune function, and reduce the toxicity of chlorpyrifos.