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Research progress on anti-HBV effects of natural compounds

 Last Update: 2022-05-24
 Source: Internet
 Author: User

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Hepatitis B virus (HBV) is a hepatotropic DNA virus.

Natural compounds are an important source for the discovery of new drugs or new drug lead molecules because of their structural diversity and complexity

The caudatin aglycone isolated from Cynanchum auriculatum has the activity of inhibiting the secretion of HBsAg and HBV DNA replication.

HE-145 (helioxanthin) and its analogs isolated from Taiwania cryptomerioides can reduce the levels of HBV DNA and RNA, and reduce the expression of core protein

Betulinic acid (BetA) extracted from Pulsatilla chinensis has the effect of inhibiting HBV DNA replication

Curcumin, a natural phenolic compound, can inhibit the expression and replication of HBV genes

Oxymatrine (OMTR) from the Sophora japonica plant has been used for decades in the treatment of hepatitis B patients in China, and its safety has been proven

Cepharanthine hydrochloride (CH) is a natural alkaloid derivative

So far, there is no clinically effective drug or method to cure hepatitis B virus infection

References

[1] Xiang Jiayao, Xu Min, Feng Yang.

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