Research report on drug resistance and genotyping of carbapenem-resistant gram-negative bacilli

At present, bacterial resistance has become a major challenge in the global public health field, and the infection situation caused by carbapenemase pro-ducing organisms (CPO) is particularly severe.

The clinical manifestations of CPO infection are widespread drug resistance, rapid spread of drug resistance, high mortality, and limited clinically available antibacterial drugs.

In March 2021, Li Dongming and others published "Resistance and Genotyping of Carbapenem-resistant Gram-negative Bacteria" in the Chinese Journal of Nosocomial Infection.

research method

A collection of 122 carbapenem-resistant gram-negative bacteria detected in clinical specimens submitted by Tianjin Third Central Hospital from November 2017 to October 2019.

Research result

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Analysis conclusion

Carbapenemase Klebsiella pneumoniae is predominantly KPC type, and Acinetobacter baumannii is predominantly OXA-23 type.

Carbapenemase resistance gene detection reagent (immunochromogenic reagent) adopts colloidal gold detection method, which can effectively identify the six carbapenemase genotypes (KPC/NDM/IMP-4/VIM/OXA-23) /OXA-48), the operation is simple, the results are intuitive and effective, and the test results can be obtained 10 minutes after spotting! To effectively control the horizontal spread of drug-resistant strains and to provide a more reliable basis for the implementation of individualized antimicrobial treatment programs, innovation leads a new era of clinical prevention and treatment of carbapenem-resistant infections!

Application scenarios:

Admission screening: screening patients at risk of CRE infection, discovering patients with colonization of potential carbapenem-resistant bacteria, preventing colonization and trans-infection, and strengthening hospital control.

Screening before medication: The resistance of different genotypes of resistant bacteria to different drugs varies greatly.

Monitoring medication: CRE screening during medication can effectively adjust medication regimen and enhance prognosis.

source:

Li Dongming,Wang Yufan,Wu Yujing,Zhang Jiandong.

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