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    Home > Food News > Food Articles > Research reveals new mechanisms for "cross-border" mosquito control of insecticidal fungi

    Research reveals new mechanisms for "cross-border" mosquito control of insecticidal fungi

    • Last Update: 2021-03-16
    • Source: Internet
    • Author: User
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    a new study by Wang Shibao Research Group of the Center for Excellence and Innovation in Molecular Plant Science of the Chinese Academy of Sciences has revealed new mechanisms for insecticide fungi to implement cross-border insect immune response and promote infection. On September 20, the study was published online in Nature -Newsletter.
    insecticidal fungus, which has great advantages in mosquito biological control and blocking the spread of pathogens, is an environmentally friendly biopesticide. "Research on the interoperability of insecticidal fungi and mosquitoes is of great importance for the development of high-efficiency bio-insecticides." Introduction by Wang Shibao, author of the paper newsletter. Previous research by the team has found that insecticidal fungi manipulate the interoperability of gut bacteria to kill mosquitoes by suppressing gut immunity. Pathogens and host insects have evolved factors, or effect factors, that can help them disrupt or inhibit the insect's immune response in a long-term "arms race" of attack and defense. However, little is known about whether insecticidal fungi also use effect factors to enter insect cells to target and regulate the expression of insect genes to suppress the host's immune response.
    In this study, researchers found that when insecticidal fungal spores first invade the walls of mosquitoes, they express highly a small molecule RNA called milR1, which binds to the vesicles that carry the material's transport. The ride", which is delivered to insect cells, binds to the AGO1 protein in the insect cells, making the host immune-related gene "silent", causing the insect's antifygal immune system Toll signaling path path "failed" (the immune path is used to produce antimicrobial peptides). When fungi invade the blood cavity of mosquitoes, the continuous expression of milR1 will activate the blackened immune response in the blood cavity, producing melanin with bactericidal effect, at this time the "smart" fungus will actively reduce the expression of milR1, once again successfully evade the mosquito's immune "attack", and finally achieve the goal of successfully infecting and killing mosquitoes.
    " study reveals for the first time the new mechanism by which fungi use small molecule RNA as an effect factor to suppress insect immune responses to effective infection. Wang said the study not only found a new pathogenic pathogenicity of insecticidal fungi, but also opened up a new research direction, providing new ideas for the development of high-efficiency biopharmaceers. (Source: Huang Xin Hejing, China Science Journal
    relevant paper information:
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