Research reveals new targets for slowing human stem cell aging

。 SIRT7 slows the aging of human-filled stem cells by inhibiting the LINE1-cGAS-STING pathline
Sirtuins is a family of homogenetic proteins of the yeast Sir2 protein in mammals and a highly conservative class of deacetylases that are dependent on the evolutionary highly conservative NAD
. Sirtuins is also known as the Longevity Protein Family because it was originally found to have the effect of extending the life of wine-making yeast. In mammals, the Srituins family has seven members (SIRT1-SIRT7), of which SIRT7 is generally considered to be located in the nucleus and plays an important role in many biological processes. So far, however, it is not known whether SIRT7 can regulate the aging of human stem cells.
A study published online June 6 in the journal Protein and Cells found that SIRT7 stabilizes isochromatin structures by interoperability with nuclear membranes and isoprome proteins, thereby suppressing natural immune path pathps and slowing the aging of human stem cells. The study was carried out by Qu Jing Research Group of the Institute of Zoology of the Chinese Academy of Sciences, Liu Guanghui Research Group, Song Mo-Ming Research Group and Zhang Weiwei Research Group of the Beijing Genomics Research Institute of the Chinese Academy of Sciences.
researchers found that SIRT7 was reduced in the expression of aging human-filled stem cells. After the knockout of SIRT7, the interoperability of the nucleoglobin and chromatin in human-charged stem cells weakens and the isochromatin is lost, which makes the genome of the isochromatin region more open, which in turn causes transcription activation of the retroviral transperson LINE1 and more frequent trans-seating. At the same time, LINE1's reverse transcription products activate the cGAS-STING natural immune signaling path, further triggering type I interferon reaction and aging-related secretion espresso, and ultimately inducing human-to-human supercharged stem cells to accelerate aging. Over-expression of SIRT7 or addition to LINE1 reverse transcriptase inhibitor 3TC (an anti-HIV drug) can effectively delay the aging of human-filled stem cells.
The study found for the first time that SIRT7 plays a key role in the stabilization and aging regulation of human stem cells by regulating the "heterochromatin-LINE1-cGAS-STING" pathline, and confirms the effectiveness of SIRT7 gene enhancement and reverse transcriptase inhibitors in delaying human stem cell aging. These findings provide new ideas and targets for interventions in aging-related diseases. (Source: Liu Runan, China Science Journal)