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Dopamine (DA) is an important monoamine neurotransmitter in the human body, involved in the regulation of various physiological functions of the central nervous system (CNS) and peripheral nervous system (PNS).
bioon.
In the early stage, the Xu Huaqiang research group of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, combined with many domestic and foreign units, analyzed and reported the high-resolution structure of multiple signal complexes such as D1R combined with selective and non-selective agonists, combined with multiple functional experimental data , Revealing the molecular mechanism of the ligand selectivity of activated D1R and the structural basis of the difference in G protein selectivity.
The study found that the overall interaction between DA and SKF81297 and D1R is similar.
The higher resolution structure allows the binding mode of PAM LY3154207 to be clearly displayed on D1R.
bioon.