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Bio-nanomachines are macromolecular machines commonly found in cells, usually in the form of multi-protein complexes, and they often perform tasks necessary for life
The nanomachine R2TP-TTT acts as a molecular chaperone to assemble other molecules in human cells
Scientists from the School of Life Sciences of the University of Sussex, in collaboration with colleagues from CNIO University of Madrid, University of Cambridge MRC-LMB and University of Leeds, used the most advanced cryo-electron microscope (cryoEM) to establish a detailed image of the R2TP-TTT nanomachine, showing The arrangement of all proteins
The lead researcher, friend of Dr.
Professor Pearl, who co-directed this work with Dr.
"Previously, we have been able to study the structure of protein molecules through X-ray crystallography, but we can usually only study them individually or individually
With the help of the RM Phillips Charitable Trust, the University of Sussex has invested millions of pounds in the establishment of cryo-electron microscopes in the School of Life Sciences
Professor Pearl said:
"Having our own instruments on site will greatly speed up the speed at which we can reveal the structure of a large number of bio-nanomachines, which are being studied by colleagues in the life sciences
Journal Reference :
Mohinder Pal, Hugo Muñoz-Hernandez, Dennis Bjorklund, Lihong Zhou, Gianluca Degliesposti, J.