Research shows that a new drug can be used to treat breast cancer

Recently, a new study published in the journal Molecular Cancer Therapeutics shows that a new drug (http:// can prevent cancer from developing chemotherapy tolerance, which will help to treat invasive breast cancer Scientists from the Cancer Institute in London found that the drug, called "bos172722", can "force" cancer cells to divide rapidly, leading to an increase in the proportion of chromosomal mismatches At present, the first clinical trial (http:// is in progress, and the treatment target is invasive triple negative breast cancer However, researchers believe it may also be effective against other rapidly growing cancers, including ovarian cancer The working mechanism of bos172722 is that it blocks the activity of a molecule called Mps1, which plays a central role in controlling cell division Mps1 participates in the organization of chromosomes during cell division, ensuring that they are correctly distributed in the offspring cells, and ensuring cell division until they are evenly separated By targeting Mps1 with bos172722, cancer cells will accelerate their death due to cell division with the wrong number of chromosomes The researchers found that cancer cells treated with Mps1 inhibitors split in just 11 minutes, compared with 52 minutes in the control group The researchers found that paclitaxel combined with bos172722 significantly reduced cell division time - from 110 minutes on paclitaxel alone to 15 minutes in combination with bos172722 All the cells treated with this combination therapy had chromosomal abnormalities and resulted in death However, the killing rate of taxol alone was only 40%.